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Diameter of the Cell-to-Cell Junctional Membrane Channels as Probed with Neutral Molecules

The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules--neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest perme...

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Published in:Science (American Association for the Advancement of Science) 1981-07, Vol.213 (4507), p.551-553
Main Authors: Schwarzmann, G., Wiegandt, H., Rose, B., Zimmerman, A., Ben-Haim, D., Loewenstein, W. R.
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Language:English
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cited_by cdi_FETCH-LOGICAL-c410t-ecd8099a786b41bded615e6832f12eacafc215e2b0eac87687a27d82378676f13
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container_issue 4507
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container_title Science (American Association for the Advancement of Science)
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creator Schwarzmann, G.
Wiegandt, H.
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Loewenstein, W. R.
description The cell-to-cell channels in the junctions of an insect salivary gland and of insect and mammalian cells in culture were probed with fluorescent molecules--neutral linear oligosaccharides, neutral branched glycopeptides, and charged linear peptides. From the molecular dimensions of the largest permeants and smallest impermeants the permeation-limiting channel diameter was obtained: 16 to 20 angstroms for the mammalian cells and 20 to 30 angstroms for the insect cells.
doi_str_mv 10.1126/science.7244653
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ispartof Science (American Association for the Advancement of Science), 1981-07, Vol.213 (4507), p.551-553
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source American Association for the Advancement of Science; JSTOR Archival Journals and Primary Sources Collection
subjects animal cells
Animal glands
Animals
Cell culture techniques
Cell interaction
Cell interactions
cell junctions
Cell Line
channels
Chironomidae
Cultured cells
DNA
Fluorescent Dyes
fluorescent probes
Giant cells
Glycopeptides
Glycopeptides - metabolism
insects
Intercellular junctions
Intercellular Junctions - ultrastructure
Mice
Mice, Inbred BALB C
Models, Molecular
Molecules
Oligosaccharides - metabolism
Plasmids
Protein Conformation
salivary gland
Salivary glands
Salivary Glands - ultrastructure
Species Specificity
title Diameter of the Cell-to-Cell Junctional Membrane Channels as Probed with Neutral Molecules
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