Overexpression of E2F-1 Is Associated with Increased Disease-free Survival in Squamous Cell Carcinoma of the Anterior Tongue

Purpose: Overexpression of E2F-1 is associated with increased invasiveness in head and neck squamous cell carcinoma cell lines in vitro , but its significance in vivo is unknown. This study sought to determine the relationship between E2F-1 and retinoblastoma protein (pRb) expression and disease out...

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Bibliographic Details
Published in:Clinical cancer research 2003-09, Vol.9 (10), p.3705-3711
Main Authors: KWONG, Rhonda A, NGUYEN, Tuan V, BOVA, Ronaldo J, KENCH, James G, COLE, Ian E, MUSGROVE, Elizabeth A, HENSHALL, Susan M, SUTHERLAND, Robert L
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - metabolism
Cell Cycle Proteins
Cell Line, Tumor
Cohort Studies
Cyclin D1 - biosynthesis
Cyclin-Dependent Kinase Inhibitor p16 - biosynthesis
Disease-Free Survival
DNA-Binding Proteins
E2F Transcription Factors
E2F1 Transcription Factor
Female
Humans
Immunohistochemistry
Ki-67 Antigen - biosynthesis
Male
Medical sciences
Middle Aged
Multivariate Analysis
Otorhinolaryngology (head neck, general aspects and miscellaneous)
Otorhinolaryngology. Stomatology
Prognosis
Proportional Hazards Models
Retinoblastoma Protein - biosynthesis
Time Factors
Tongue Neoplasms - diagnosis
Tongue Neoplasms - metabolism
Transcription Factors - biosynthesis
Treatment Outcome
Tumors
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Summary:Purpose: Overexpression of E2F-1 is associated with increased invasiveness in head and neck squamous cell carcinoma cell lines in vitro , but its significance in vivo is unknown. This study sought to determine the relationship between E2F-1 and retinoblastoma protein (pRb) expression and disease outcome in squamous cell carcinoma (SCC) of the anterior tongue. Experimental Design : pRb and E2F-1 protein expression was assessed by immunohistochemistry in a cohort of 145 patients with SCC of the anterior tongue. The outcomes examined were time to disease recurrence or death. The relationships between E2F-1 or pRb expression and outcome were assessed by univariate and multivariate Cox’s proportional hazards model, with or without clinicopathological covariates, including nodal status, disease stage, treatment status, and molecular markers (cyclin D1, p16 INK4A , and Ki-67) previously measured in this cohort. Results: On univariate analysis, increased expression of E2F-1 (>35% of positive-stained nuclei) was associated with increased disease-free survival (DFS; hazard ratio [HR]: 0.35; P = 0.04) and increased overall survival (OS; HR: 0.33; P = 0.06). Decreased expression of pRb (
ISSN:1078-0432
1557-3265