Estrogens, homocysteine, vasodilatation and menopause: basic mechanisms, interactions and clinical implications

Estrogens influence the independent cardiovascular risk factor homocysteine as well as vasodilatation. Homocysteine alone also influences vasodilatation, indicating a relational triangle that seems important in interpreting the isolated effects of estrogens on homocysteine metabolism and vasoreactiv...

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Published in:Gynecological endocrinology 2003-08, Vol.17 (4), p.339-354
Main Authors: SMOLDERS, R. G. V, VAN DER MOOREN, M. J, SIPKEMA, P, KENEMANS, P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - prevention & control
Clinical Trials as Topic
Estrogen Replacement Therapy
Estrogens - physiology
Female
Fundamental and applied biological sciences. Psychology
Homocysteine - metabolism
Homocysteine - physiology
Humans
Mammalian female genital system
Morphology. Physiology
Postmenopause - physiology
Vasodilation - physiology
Vertebrates: reproduction
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container_end_page 354
container_issue 4
container_start_page 339
container_title Gynecological endocrinology
container_volume 17
creator SMOLDERS, R. G. V
VAN DER MOOREN, M. J
SIPKEMA, P
KENEMANS, P
description Estrogens influence the independent cardiovascular risk factor homocysteine as well as vasodilatation. Homocysteine alone also influences vasodilatation, indicating a relational triangle that seems important in interpreting the isolated effects of estrogens on homocysteine metabolism and vasoreactivity. This paper gives an overview of the current understanding regarding vasoreactivity, homocysteine metabolism and the role of estrogens. This is placed against the background of the clinical trials on the effect of postmenopausal hormone replacement therapy on homocysteine levels and addresses the importance of the interaction between homocysteine, estrogens and vasoreactivity.
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Biological and medical sciences
Cardiovascular Diseases - physiopathology
Cardiovascular Diseases - prevention & control
Clinical Trials as Topic
Estrogen Replacement Therapy
Estrogens - physiology
Female
Fundamental and applied biological sciences. Psychology
Homocysteine - metabolism
Homocysteine - physiology
Humans
Mammalian female genital system
Morphology. Physiology
Postmenopause - physiology
Vasodilation - physiology
Vertebrates: reproduction
title Estrogens, homocysteine, vasodilatation and menopause: basic mechanisms, interactions and clinical implications
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