Clinical and pathological observations in English cocker spaniels with primary metabolic vitamin E deficiency and retinal pigment epithelial dystrophy

Fifteen English cocker spaniels with confirmed vitamin E deficiency were examined physically, ophthalmologically and neurologically. Eleven of them had clinical signs of neurological dysfunction which included ataxia, proprioceptive deficits, abnormal spinal reflexes and muscle weakness. In the two...

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Bibliographic Details
Published in:Veterinary record 2003-09, Vol.153 (10), p.287-292
Main Authors: McLellan, G. J., Cappello, R., Mayhew, I. G., Elks, R., Lybaert, P., Watté, C., Bedford, P. G. C.
Format: Article
Language:English
Subjects:
Animals
Ataxia - etiology
Ataxia - veterinary
Dog Diseases - epidemiology
Dog Diseases - genetics
Dog Diseases - pathology
Dogs
Electromyography - veterinary
England - epidemiology
Female
Male
Neurologic Examination - veterinary
Pedigree
Pigment Epithelium of Eye - pathology
Prospective Studies
Retinal Degeneration - complications
Retinal Degeneration - epidemiology
Retinal Degeneration - veterinary
Retrospective Studies
Spinal Cord Diseases - complications
Spinal Cord Diseases - epidemiology
Spinal Cord Diseases - veterinary
Vitamin E Deficiency - complications
Vitamin E Deficiency - epidemiology
Vitamin E Deficiency - veterinary
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Summary:Fifteen English cocker spaniels with confirmed vitamin E deficiency were examined physically, ophthalmologically and neurologically. Eleven of them had clinical signs of neurological dysfunction which included ataxia, proprioceptive deficits, abnormal spinal reflexes and muscle weakness. In the two dogs examined histopathologically there was central neuronal fibre degeneration with prominent neuroaxonal dystrophy, particularly within the sensory relay nuclei of the brainstem, and one of the dogs had severe intestinal lipofuscinosis.
ISSN:0042-4900
2042-7670
DOI:10.1136/vr.153.10.287