An early cytoplasmic change before Lewy body maturation : an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism

Neurons containing a central pale area which may possibly represent an early cytoplasmic change before Lewy body maturation were observed in the substantia nigra from a rare autopsy case of juvenile parkinsonism. Ultrastructurally, such neurons exhibited cytoplasmic swelling along with disappearance...

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Bibliographic Details
Published in:Acta neuropathologica 1993, Vol.85 (4), p.445-448
Main Authors: HAYASHIDA, K, OYANAGI, S, MIZUTANI, Y, YOKOCHI, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - pathology
Child
Cytoplasm - ultrastructure
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Endoplasmic Reticulum - pathology
Endoplasmic Reticulum - ultrastructure
Female
Humans
Lewy Bodies - pathology
Medical sciences
Microscopy, Electron
Neurology
Parkinson Disease - pathology
Ribosomes - ultrastructure
Substantia Nigra - pathology
Substantia Nigra - ultrastructure
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Summary:Neurons containing a central pale area which may possibly represent an early cytoplasmic change before Lewy body maturation were observed in the substantia nigra from a rare autopsy case of juvenile parkinsonism. Ultrastructurally, such neurons exhibited cytoplasmic swelling along with disappearance of the rough endoplasmic reticulum from the central part of the perikaryon. The pale central cytoplasm was replaced by numerous-cored vesicles, mitochondria, ribosome-like granules and a few Lewy body filaments. The relation of this central pale area to the pale body is discussed.
ISSN:0001-6322
1432-0533
DOI:10.1007/bf00334457