Mechanisms of high-density lipoprotein cholesterol effects on the endothelial function in hyperlipemia

• Published in: Metabolism, clinical and experimental clinical and experimental, 2003-09, Vol.52 (9), p.1191-1195
• Main Authors: LUPATTELLI, Graziana, MARCHESI, Simona, LOMBARDINI, Rita, SIEPI, Donatella, BAGAGLIA, Francesco, PIRRO, Matteo, CIUFFETTI, Giovanni, SCHILLACI, Giuseppe, MANNARINO, Elmo
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Blood Flow Velocity; Body Mass Index; Brachial Artery - physiopathology; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Disorders of blood lipids. Hyperlipoproteinemia; E-Selectin - blood; Endothelium, Vascular - physiopathology; Female; Humans; Hyperlipidemias - blood; Hyperlipidemias - physiopathology; Intercellular Adhesion Molecule-1 - blood; Lipoproteins, LDL - blood; Male; Medical sciences; Metabolic diseases; Middle Aged; Triglycerides - blood; Vascular Cell Adhesion Molecule-1 - blood; Vasodilation
• ISSN: 0026-0495; 1532-8600
• DOI: 10.1016/s0026-0495(03)00157-4

High-density lipoprotein-cholesterol (HDL-c) has a favorable influence on the endothelial function, but the mechanisms of this protective action are not fully understood. We studied lipid parameters, soluble adhesion molecules (vascular cell adhesion molecule-1 [VCAM-1], intercellular adhesion molecule [ICAM-1], E-selectin) oxidized low-density lipoproteins (LDL), and brachial-artery flow-mediated vasodilation (FMV) in 184 hyperlipemic patients (90 men, age 54 +/- 10 years, waist/hip circumference ratio 0.89 +/- 0.07, LDL-cholesterol [LDL-c] 4.9 +/- 1.3 mmol/L, triglycerides 1.8 +/- 0.9 mmol/L, HDL-c 1.3 +/- 0.5 mmol/L) after excluding those with current smoking, diabetes, hypertension, and vascular diseases. Patients were divided into 2 groups on the basis of HDL-c levels: < 1.03 mmol/L (n = 53) v >or= 1.03 mmol/L (n = 131). Patients with low HDL-c showed significantly lower LDL-c (P