Antigen-specific IgA and IgG responses in calves inoculated intranasally with ovalbumin encapsulated in poly( dl-lactide-co-glycolide) microspheres

The immunogenicity of proteins encapsulated in poly( dl-lactide-co-glycolide) (PLG) microspheres has not been investigated to any extent in large animal models. In this study, IgG and IgA responses to ovalbumin (OVA), encapsulated in microspheres was investigated following intranasal inoculation int...

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Bibliographic Details
Published in:Vaccine 2003-10, Vol.21 (27), p.4472-4480
Main Authors: Kavanagh, Owen V, Earley, Bernadette, Murray, Margaret, Foster, Colin J, Adair, Brian M
Format: Article
Language:English
Subjects:
Administration, Intranasal
Animal models
Animals
Applied microbiology
Biological and medical sciences
Cattle
Drug Compounding
Experiments
Flow cytometric analysis
Fundamental and applied biological sciences. Psychology
Immunization, Secondary
Immunogenicity
Immunoglobulin A - biosynthesis
Immunoglobulin G - biosynthesis
Kinetics
Lactic Acid
Microbiology
Microspheres
Molecular weight
Ovalbumin
Ovalbumin - administration & dosage
Ovalbumin - immunology
Particle Size
Poly( dl-lactide-co-glycolide) microspheres
poly(DL-lactide-co-glycolide)
Polyglycolic Acid
Polylactic Acid-Polyglycolic Acid Copolymer
Polymers
Polyvinyl alcohol
Proteins
Proteins - chemistry
Studies
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Description
Summary:The immunogenicity of proteins encapsulated in poly( dl-lactide-co-glycolide) (PLG) microspheres has not been investigated to any extent in large animal models. In this study, IgG and IgA responses to ovalbumin (OVA), encapsulated in microspheres was investigated following intranasal inoculation into calves. Scanning electron microscopy and flow cytometric analysis demonstrated a uniform microsphere population with a diameter of
ISSN:0264-410X
1873-2518
DOI:10.1016/S0264-410X(03)00432-8