Endothelin-1 stimulated phospholipase D in A10 vascular smooth muscle derived cells is dependent on tyrosine kinase Evidence for involvement in stimulation of mitogenesis

The mechanism whereby endothelin stimulates motogenesis of vascular smooth muscle cells is not understood. Here we show that endothelin-1 stimulates phospholipase D by a protein kinase C and tyrosine kinase dependent mechanism, and present evidence that implicate the phosphatidic acid formed by phos...

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Bibliographic Details
Published in:FEBS letters 1993-05, Vol.322 (2), p.147-150
Main Authors: Wilkes, Lesley C., Patel, Viral, Purkiss, John R., Boarder, Michael R.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Division - physiology
Cell physiology
Cells, Cultured
concentration giving 50% of maximal inhibition
Endothelin
endothelin-1
Endothelins - physiology
ET-1
Fundamental and applied biological sciences. Psychology
Hormonal regulation
IC50
Mitogenesis
Molecular and cellular biology
Muscle, Smooth, Vascular - enzymology
PBut
phorbol myristate acetate
phosphatidic acid
phosphatidylbutanol
phospholipase C
Phospholipase D
Phospholipase D - metabolism
PKC
PLC
PLD
PMA
Protein kinase C
Protein Kinase C - physiology
Protein-Tyrosine Kinases - physiology
Rats
Smooth muscle cell
Thymidine - metabolism
Tritium
Tyrosine kinase
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Summary:The mechanism whereby endothelin stimulates motogenesis of vascular smooth muscle cells is not understood. Here we show that endothelin-1 stimulates phospholipase D by a protein kinase C and tyrosine kinase dependent mechanism, and present evidence that implicate the phosphatidic acid formed by phospholipase D in the mitogenic response.
ISSN:0014-5793
1873-3468
DOI:10.1016/0014-5793(93)81556-F