Epidemiology of Human Immunodeficiency Virus Type 1 Infection among Homosexual Men Participating in Hepatitis B Vaccine Trials in Amsterdam, New York City, and San Francisco, 1978–1990

Homosexual/bisexual men from Amsterdam, The Netherlands, New York, New York, and San Francisco, California, were entered into trials of the efficacy of hepatitis B vaccine shortly before the acquired immunodeficiency syndrome (AIDS) epidemic was recognized (1978–1980). The authors analyzed data, inc...

Full description

Saved in:
Bibliographic Details
Published in:American journal of epidemiology 1993-04, Vol.137 (8), p.909-915
Main Authors: van Griensven, Godfried J. P., Hessol, Nancy A., Koblin, Beryl A., Byers, Robert H., O'Malley, Paul M., Albrecht-van Lent, Nel, Buchbinder, Susan P., Taylor, Patricia E., Stevens, Cladd E., Coutinho, Roel A.
Format: Article
Language:English
Subjects:
acquired immunodeficiency syndrome
AIDS/HIV
Biological and medical sciences
Cohort Studies
Hepatitis B - complications
Hepatitis B - epidemiology
Hepatitis B - prevention & control
Hepatitis B Vaccines
hepatitis B virus
HIV
HIV Infections - complications
HIV Infections - epidemiology
HIV-1
homosexuality
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Incidence
Male
Medical sciences
Netherlands - epidemiology
New York City - epidemiology
Prevalence
San Francisco - epidemiology
sex behavior
Sexual Behavior
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Homosexual/bisexual men from Amsterdam, The Netherlands, New York, New York, and San Francisco, California, were entered into trials of the efficacy of hepatitis B vaccine shortly before the acquired immunodeficiency syndrome (AIDS) epidemic was recognized (1978–1980). The authors analyzed data, including serial blood samples tested for antibody to human immunodeficiency virus type 1 (HIV-1) as well as demographic and behavioral information, to characterize the spread of HIV-1 infection within the cohorts. By the end of 1982, the cumulative incidence of HIV-1 infection was 7.5% in Amsterdam, 26.8% in New York City, and 42.6% in San Francisco. Covariate analysis showed that differences in sexual activity (number of male sexual partners) and correlates of sexual activity (age and hepatitis B incidence) accounted for the differences in incidence of HIV-1 infection between the New York City and San Francisco cohorts. These covariates did not explain the lower incidence in the Amsterdam cohort. In conclusion, significant differences were found in the spread of HIV-1 in cohorts of homosexual men in Amsterdam, New York City, and San Francisco. These dissimilarities were probably due to a combination of differences in sexual activity at the time the epidemic began and a later introduction of HIV-1 in Amsterdam.
ISSN:0002-9262
1476-6256
DOI:10.1093/oxfordjournals.aje.a116752