A New Titanium Tetrachloride Mediated Annulation of α-Aryl-Substituted Carbonyl Compounds with Alkynes:  A Simple and Highly Efficient Method for the Regioselective Synthesis of Polysubstituted Naphthalene Derivatives

A new straightforward procedure has been developed for the synthesis of polysubstituted naphthalene derivatives. The reaction of α-aryl-substituted carbonyl compounds with terminal or internal alkynes in the presence of TiCl4 regioselectively generates substituted naphthalene derivatives in good to...

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Bibliographic Details
Published in:Journal of organic chemistry 2003-10, Vol.68 (20), p.7915-7917
Main Authors: Kabalka, George W, Ju, Yuhong, Wu, Zhongzhi
Format: Article
Language:English
Subjects:
Chemistry
Condensed benzenic and aromatic compounds
Exact sciences and technology
Organic chemistry
Preparations and properties
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Summary:A new straightforward procedure has been developed for the synthesis of polysubstituted naphthalene derivatives. The reaction of α-aryl-substituted carbonyl compounds with terminal or internal alkynes in the presence of TiCl4 regioselectively generates substituted naphthalene derivatives in good to excellent yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo034330o