Lymphomatoid papulosis associated with mycosis fungoides: a study of 21 patients including analyses for clonality

Although an association of lymphomatoid papulosis (LyP) with mycosis fungoides (MF) is recognized, our understanding of this relation is limited. We sought to document the clinical experience at the University of California, San Francisco, in 21 patients who had both LyP and MF and to do clonality s...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2003-10, Vol.49 (4), p.620-623
Main Authors: Zackheim, Herschel S, Jones, Carol, LeBoit, Philip E, Kashani-Sabet, Mohammed, McCalmont, Timothy H, Zehnder, James
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Biological and medical sciences
Child
Child, Preschool
Cloning, Molecular
Dermatology
Female
Gene Rearrangement, T-Lymphocyte - genetics
Gene Rearrangement, T-Lymphocyte - immunology
Hematologic and hematopoietic diseases
Humans
Immunophenotyping
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphomatoid Papulosis - complications
Lymphomatoid Papulosis - genetics
Male
Medical sciences
Middle Aged
Mycosis Fungoides - complications
Mycosis Fungoides - genetics
Polymerase Chain Reaction
Skin involvement in other diseases. Miscellaneous. General aspects
T-Lymphocytes - immunology
T-Lymphocytes - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although an association of lymphomatoid papulosis (LyP) with mycosis fungoides (MF) is recognized, our understanding of this relation is limited. We sought to document the clinical experience at the University of California, San Francisco, in 21 patients who had both LyP and MF and to do clonality studies in 7 of those patients in whom this was possible. We conducted chart review of the 21 patients and analysis for T-cell receptor-γ gene rearrangements by the polymerase chain reaction. Of 54 patients, 21 (39%) with LyP had associated MF. LyP preceded MF in 14 (67%), MF preceded LyP in 4 (19%), and there was concurrent appearance in 3 (14%). Of the 21 patients, 20 (95%) were type A and only 1 (5%) was type B. An identical clone was found in lesions of both LyP and MF in all 7 patients in whom analysis was possible. Findings of this study strengthen the idea that LyP and MF are related T-cell lymphoproliferative disorders.
ISSN:0190-9622
1097-6787
DOI:10.1067/S0190-9622(03)01577-9