Metastasis of renal cell carcinoma to haemangioblastoma of the spinal cord in von Hippel–Lindau disease: case report and review of the literature

A case is presented demonstrating the unusual phenomenon of a renal cell carcinoma metastasising to a spinal haemangioblastoma in a patient with von Hippel–Lindau (VHL) disease. Recent advances in the molecular biology of VHL disease relevant to possible mechanisms of tumour-to-tumour metastasis are...

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Bibliographic Details
Published in:Pathology 2003, Vol.35 (3), p.224-227
Main Authors: Abou-Hamden, Amal, Koszyca, Barbara, Carney, Paul G., Sandhu, Nindi, Blumbergs, Peter C.
Format: Article
Language:English
Subjects:
Adult
Anion Exchange Protein 1, Erythrocyte - metabolism
Biological and medical sciences
Biomarkers, Tumor - metabolism
Carcinoma, Renal Cell - metabolism
Carcinoma, Renal Cell - secondary
Carcinoma, Renal Cell - surgery
haemangioblastoma
Hemangioblastoma - metabolism
Hemangioblastoma - pathology
Hemangioblastoma - surgery
Humans
Immunohistochemistry
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Kidney Neoplasms - surgery
Kidneys
Magnetic Resonance Imaging
Male
Medical sciences
Mucin-1 - metabolism
Neoplasms, Multiple Primary - metabolism
Neoplasms, Multiple Primary - pathology
Nephrology. Urinary tract diseases
Neurology
renal cell carcinoma
Spinal cord metastasis
Spinal Cord Neoplasms - metabolism
Spinal Cord Neoplasms - secondary
Spinal Cord Neoplasms - surgery
Treatment Outcome
Tumors of the nervous system. Phacomatoses
Tumors of the urinary system
von Hippel-Lindau Disease - complications
von Hippel-Lindau Disease - metabolism
von Hippel-Lindau Disease - pathology
von Hippel–Lindau disease
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Description
Summary:A case is presented demonstrating the unusual phenomenon of a renal cell carcinoma metastasising to a spinal haemangioblastoma in a patient with von Hippel–Lindau (VHL) disease. Recent advances in the molecular biology of VHL disease relevant to possible mechanisms of tumour-to-tumour metastasis are briefly reviewed.
ISSN:0031-3025
1465-3931
DOI:10.1080/003130203100023191