Serum resistin level in essential hypertension patients with different glucose tolerance

• Published in: Diabetic medicine 2003-10, Vol.20 (10), p.828-831
• Main Authors: Zhang, J.-L., Qin, Y.-W., Zheng, X., Qiu, J.-L., Zou, D.-J.
• Format: Article
• Language: English
• Subjects: Adult; Area Under Curve; Arterial hypertension. Arterial hypotension; Biological and medical sciences; Blood and lymphatic vessels; blood glucose; Blood Glucose - analysis; Cardiology. Vascular system; Case-Control Studies; Clinical manifestations. Epidemiology. Investigative techniques. Etiology; Diabetes Mellitus, Type 2 - blood; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Glucose Tolerance Test; Hormones, Ectopic - blood; Humans; hypertension; Hypertension - blood; Insulin - blood; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Linear Models; Male; Medical sciences; Middle Aged; Resistin
• ISSN: 0742-3071; 1464-5491
• DOI: 10.1046/j.1464-5491.2003.01057.x

Aims  To investigate resistin concentrations in patients with essential hypertension and different glucose tolerance and the relationship between serum resistin level and blood glucose. Methods  Sixty‐five patients with essential hypertension [13 with Type 2 diabetes mellitus (DM), 26 with impaired glucose tolerance (IGT), and 26 with normal glucose tolerance (NGT); 30 males, 35 females] were studied. Fasting serum resistin concentrations were measured by enzyme immunoassay (EIA). Oral glucose tolerance tests and insulin release tests were used to calculate glucose area under the curve (AUCG), the ratio of insulin to glucose (ΔI30/ΔG30), and insulin sensitivity index (ISI) according to Cederholm's formula. Results  Fasting serum resistin concentrations (µg/l) in DM (34.9 ± 10.2) patients were significantly higher than those in IGT (25.1 ± 10.4) (P