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EI-1941-1 and -2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941: II. Taxonomy of Producing Strain, Fermentation, Isolation, Physico-chemical Properties, and Biological Properties

EI-1941-1 and -2, novel interleukin-1β converting enzyme (ICE) inhibitors, were isolated from the culture broths of Farrowia sp. E-1941. EI-1941-1 and -2 selectively inhibited the human recombinant ICE activity with IC50 values of 0.086 and 0.006μM, respectively. Taxonomy and fermentation of the pro...

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Published in:	Journal of antibiotics 2003/07/25, Vol.56(7), pp.603-609
Main Authors:	KOIZUMI, FUMITO, ISHIGURO, HIROKI, ANDO, KATSUHIKO, KONDO, HIDEMASA, YOSHIDA, MAYUMI, MATSUDA, YUZURU, NAKANISHI, SATOSHI
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Language:	English
Subjects:	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Caspase Inhibitors Chromatography, Gel Cyclohexanones - chemistry Cyclohexanones - isolation & purification Cyclohexanones - pharmacology Cysteine Proteinase Inhibitors - biosynthesis Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - isolation & purification Cysteine Proteinase Inhibitors - pharmacology Epoxy Compounds - chemistry Epoxy Compounds - isolation & purification Epoxy Compounds - pharmacology Farrowia Fermentation Humans Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Serpins - biosynthesis Serpins - chemistry Serpins - isolation & purification Serpins - pharmacology Soil Microbiology Sordariales - chemistry Sordariales - metabolism Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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container_issue	7
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container_title	Journal of antibiotics
container_volume	56
creator	KOIZUMI, FUMITO ISHIGURO, HIROKI ANDO, KATSUHIKO KONDO, HIDEMASA YOSHIDA, MAYUMI MATSUDA, YUZURU NAKANISHI, SATOSHI
description	EI-1941-1 and -2, novel interleukin-1β converting enzyme (ICE) inhibitors, were isolated from the culture broths of Farrowia sp. E-1941. EI-1941-1 and -2 selectively inhibited the human recombinant ICE activity with IC50 values of 0.086 and 0.006μM, respectively. Taxonomy and fermentation of the producing strain and isolation, physico-chemical properties, structure elucidation, and biological properties of EI-1941-1 and -2 are described.
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Drug treatments ; Serpins - biosynthesis ; Serpins - chemistry ; Serpins - isolation & purification ; Serpins - pharmacology ; Soil Microbiology ; Sordariales - chemistry ; Sordariales - metabolism ; Spectrometry, Mass, Fast Atom Bombardment ; Spectrophotometry, Infrared ; Spectrophotometry, Ultraviolet</subject><ispartof>The Journal of Antibiotics, 2003/07/25, Vol.56(7), pp.603-609</ispartof><rights>Japan Antibiotics Research Association</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,1878,27911,27912</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15118818$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14513902$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KOIZUMI, FUMITO</creatorcontrib><creatorcontrib>ISHIGURO, HIROKI</creatorcontrib><creatorcontrib>ANDO, KATSUHIKO</creatorcontrib><creatorcontrib>KONDO, HIDEMASA</creatorcontrib><creatorcontrib>YOSHIDA, MAYUMI</creatorcontrib><creatorcontrib>MATSUDA, YUZURU</creatorcontrib><creatorcontrib>NAKANISHI, SATOSHI</creatorcontrib><title>EI-1941-1 and -2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. 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Antiinflammatory agents</subject><subject>Caspase Inhibitors</subject><subject>Chromatography, Gel</subject><subject>Cyclohexanones - chemistry</subject><subject>Cyclohexanones - isolation & purification</subject><subject>Cyclohexanones - pharmacology</subject><subject>Cysteine Proteinase Inhibitors - biosynthesis</subject><subject>Cysteine Proteinase Inhibitors - chemistry</subject><subject>Cysteine Proteinase Inhibitors - isolation & purification</subject><subject>Cysteine Proteinase Inhibitors - pharmacology</subject><subject>Epoxy Compounds - chemistry</subject><subject>Epoxy Compounds - isolation & purification</subject><subject>Epoxy Compounds - pharmacology</subject><subject>Farrowia</subject><subject>Fermentation</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Molecular Structure</subject><subject>Pharmacology. 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subjects	Biological and medical sciences Bones, joints and connective tissue. Antiinflammatory agents Caspase Inhibitors Chromatography, Gel Cyclohexanones - chemistry Cyclohexanones - isolation & purification Cyclohexanones - pharmacology Cysteine Proteinase Inhibitors - biosynthesis Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - isolation & purification Cysteine Proteinase Inhibitors - pharmacology Epoxy Compounds - chemistry Epoxy Compounds - isolation & purification Epoxy Compounds - pharmacology Farrowia Fermentation Humans Medical sciences Microbial Sensitivity Tests Molecular Structure Pharmacology. Drug treatments Serpins - biosynthesis Serpins - chemistry Serpins - isolation & purification Serpins - pharmacology Soil Microbiology Sordariales - chemistry Sordariales - metabolism Spectrometry, Mass, Fast Atom Bombardment Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
title	EI-1941-1 and -2, Novel Interleukin-1β Converting Enzyme Inhibitors Produced by Farrowia sp. E-1941: II. Taxonomy of Producing Strain, Fermentation, Isolation, Physico-chemical Properties, and Biological Properties
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