Conjugation of poor inhibitors with surface binding groups: a strategy to improve inhibition

Conjugation of surface binding groups with inhibitors for carbonic anhydrase leads to the conversion of weak inhibitors to strong inhibitors.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2003-09 (18), p.2328-2329
Main Authors: Roy, Bidhan C, Hegge, Ryan, Rosendahl, Theresa, Jia, Xiao, Lareau, Rachael, Mallik, Sanku, Srivastava, D K
Format: Article
Language:English
Subjects:
Binding, Competitive
Carbonic Anhydrase Inhibitors - chemical synthesis
Carbonic Anhydrase Inhibitors - chemistry
Carbonic Anhydrase Inhibitors - metabolism
Carbonic Anhydrases - metabolism
Catalysis
Histidine - chemistry
Kinetics
Metals, Heavy - chemistry
Metals, Heavy - metabolism
Models, Chemical
Molecular Structure
Organometallic Compounds - chemistry
Organometallic Compounds - metabolism
Protein Binding
Sulfonamides - chemical synthesis
Sulfonamides - chemistry
Sulfonamides - metabolism
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Description
Summary:Conjugation of surface binding groups with inhibitors for carbonic anhydrase leads to the conversion of weak inhibitors to strong inhibitors.
ISSN:1359-7345
DOI:10.1039/b305179j