Epidermal viral immunity induced by CD8alpha+ dendritic cells but not by Langerhans cells

The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we sh...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2003-09, Vol.301 (5641), p.1925-1928
Main Authors: Allan, Rhys S, Smith, Chris M, Belz, Gabrielle T, van Lint, Allison L, Wakim, Linda M, Heath, William R, Carbone, Francis R
Format: Article
Language:English
Subjects:
Animals
Antigen Presentation
Antigens, CD - analysis
Antigens, Viral - immunology
CD8 Antigens - analysis
Cell Separation
Chimera
Cytotoxicity, Immunologic
Dendritic Cells - immunology
Epidermis - immunology
H-2 Antigens - analysis
H-2 Antigens - immunology
Herpes Simplex - immunology
Herpesvirus 1, Human - immunology
Histocompatibility Antigens Class II - analysis
Langerhans Cells - immunology
Lectins, C-Type - analysis
Lymph Nodes - immunology
Lymphocyte Activation
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Transgenic
Minor Histocompatibility Antigens
Receptors, Cell Surface - analysis
T-Lymphocytes, Cytotoxic - immunology
Viral Envelope Proteins - immunology
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Summary:The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8alpha+ dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.
ISSN:1095-9203