High Levels of Expression of Human Stromal Cell―Derived Factor-1 Are Associated with Worse Prognosis in Patients with Stage II Pancreatic Ductal Adenocarcinoma

• Published in: Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2010-10, Vol.19 (10), p.2598-2604
• Main Authors: LIANG, John J, SHAOBO ZHU, BRUGGEMAN, Richard, ZAINO, Richard J, EVANS, Douglas B, FLEMING, Jason B, GOMEZ, Henry F, ZANDER, Dani S, HUAMIN WANG
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Biological and medical sciences; Biomarkers, Tumor - biosynthesis; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Chemokine CXCL12 - biosynthesis; Disease-Free Survival; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunohistochemistry; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Mice; Middle Aged; Neoplasm Staging; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Prognosis; Tumors
• ISSN: 1055-9965; 1538-7755
• DOI: 10.1158/1055-9965.EPI-10-0405

Stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, have been shown to mediate invasiveness and metastatic behavior in a number of cancers, including ovarian, prostate, bladder, breast, and pancreatic cancers. The expression and significance of SDF-1 in pancreatic ductal adenocarcinoma (PDA) have not been systematically studied. We examined the expression of SDF-1 by immunohistochemistry using a mouse anti-human SDF-1/CXCL12 antibody (dilution 1:300) and a tissue microarray consisting of 72 stage II PDAs from pancreaticoduodenectomy specimens. The staining results were categorized as SDF-1-high (SDF-1-H; cytoplasmic staining of ≥10% of tumor cells) or SDF-1-low (SDF-1-L; no staining or staining of