High prevalence of MMTV-like env gene sequences in gestational breast cancer

Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to expl...

Full description

Saved in:
Bibliographic Details
Published in:Medical oncology (Northwood, London, England) London, England), 2003-01, Vol.20 (3), p.233-236
Main Authors: Wang, Y, Melana, S M, Baker, B, Bleiweiss, I, Fernandez-Cobo, M, Mandeli, J F, Holland, J F, Pogo, B G T
Format: Article
Language:English
Subjects:
Animals
Breast cancer
Breast Neoplasms - genetics
Breast Neoplasms - virology
Carcinoma, Ductal - genetics
Carcinoma, Ductal - virology
DNA, Neoplasm
Female
Genes, env - genetics
Hormones - pharmacology
Humans
Lactation
Mammary Tumor Virus, Mouse - genetics
Mice
Middle Aged
Mouse mammary tumor virus
Neoplasm Invasiveness
Oncology
Pregnancy
Prognosis
Response Elements
Terminal Repeat Sequences - genetics
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Gestational breast cancer (BC) is generally associated with rapid growth and increased mortality. Because the presence of MMTV-like sequences in BC has been associated with laminin receptor expression, a marker of poor prognosis, gestational BCs were analyzed for MMTV env gene-like sequences to explore whether MMTV-like sequences were also associated with its adverse outcome. Whereas 30-38% of sporadic BC have the sequences, in gestational BC the prevalence is 62%. We suggest that hormonal response elements present in the MMTV-like LTR may play a role in promoting cell growth, as they do in the mouse system.
ISSN:1357-0560
1357-0560
1559-131X
DOI:10.1385/MO:20:3:233