Naproxen as an alternative to aspirin for the treatment of arthritis of rheumatic fever: a randomized trial

We performed a prospective, randomized, open-label equivalence study comparing the use of naproxen to aspirin in 33 patients with rheumatic fever. The mean time until resolution of arthritis was 2.9±2.9 days in both groups. Liver enzyme elevations were more frequent in the aspirin group (P=.002). We...

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Bibliographic Details
Published in:The Journal of pediatrics 2003-09, Vol.143 (3), p.399-401
Main Authors: Hashkes, Philip J., Tauber, Tsivia, Somekh, Eli, Brik, Riva, Barash, Judith, Mukamel, Masza, Harel, Liora, Lorber, Abraham, Berkovitch, Matityahu, Uziel, Yosef
Format: Article
Language:English
Subjects:
Adolescent
Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Aspirin - pharmacokinetics
Aspirin - therapeutic use
Biological and medical sciences
Child
Child, Preschool
Diseases of the osteoarticular system
Female
Humans
Male
Medical sciences
Miscellaneous. Osteoarticular involvement in other diseases
Naproxen - pharmacokinetics
Naproxen - therapeutic use
Prospective Studies
Rheumatic Fever - drug therapy
Therapeutic Equivalency
Time Factors
Treatment Outcome
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Summary:We performed a prospective, randomized, open-label equivalence study comparing the use of naproxen to aspirin in 33 patients with rheumatic fever. The mean time until resolution of arthritis was 2.9±2.9 days in both groups. Liver enzyme elevations were more frequent in the aspirin group (P=.002). We conclude that naproxen is as effective, is easier to use, and is safer than aspirin in the treatment of the arthritis of rheumatic fever.
ISSN:0022-3476
1097-6833
DOI:10.1067/S0022-3476(03)00388-3