Antimicrobial potentiality of a new non-antibiotic: the cardiovascular drug oxyfedrine hydrochloride

Ten cardiovascular drugs, having diverse pharmacological action, were screened for possible antimicrobial property against known eight sensitive bacteria, belonging to Gram positive and Gram negative types. Although five drugs failed to show antimicrobial activity and three had moderate antimicrobia...

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Bibliographic Details
Published in:Microbiological research 2003-01, Vol.158 (3), p.259-264
Main Authors: Mazumdar, Kaushiki, Ganguly, Kumkum, Kumar, K. Asok, Dutta, N.K., Chakrabarty, A.N., Dastidar, Sujata G.
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antimicrobial activity
Antimicrobic
Bacteriology
Biological and medical sciences
Cardiotonic Agents - pharmacology
Cardiovascular Agents - pharmacology
Cardiovascular drug
Fundamental and applied biological sciences. Psychology
Gram-Negative Bacteria - drug effects
Gram-Positive Bacteria - drug effects
Male
Mice
Microbial Sensitivity Tests
Microbiology
Non antibiotic
Oxyfedrine
Oxyfedrine - pharmacology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Salmonella Infections, Animal - drug therapy
Salmonella typhimurium - drug effects
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Summary:Ten cardiovascular drugs, having diverse pharmacological action, were screened for possible antimicrobial property against known eight sensitive bacteria, belonging to Gram positive and Gram negative types. Although five drugs failed to show antimicrobial activity and three had moderate antimicrobial action, oxyfedrine HCl and dobutamine were seen to possess pronounced antimicrobial property. Oxyfedrine was further tested in vitro against 471 strains of bacteria from two Gram positive and fourteen Gram negative genera. The minimum inhibitory concentration (MIC) of oxyfedrine was determined by agar dilution method, which ranged from 50–200 μg/ml in most of the strains, while some strains were inhibited at even lower concentrations. In animal experiments, this compound was capable of offering significant protection to Swiss strain of white mice, challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella typhimurium at concentrations of 15, 30 and 60 μg/mouse. The in vivo results were highly significant according to chi-square test.
ISSN:0944-5013
1618-0623
DOI:10.1078/0944-5013-00204