Association between apolipoprotein E genotype and outcome of traumatic brain injury

The prognosis of traumatic brain injury is quite variable and not fully explained by the known factors. This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Over a period of twelve months, we prospectively studied 100 patients who...

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Bibliographic Details
Published in:Acta neurochirurgica 2003-08, Vol.145 (8), p.649-654
Main Authors: Chiang, M-F, Chang, J-G, Hu, C-J
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Apolipoproteins
Apolipoproteins E - genetics
Brain damage
Brain Injuries - genetics
Brain Injuries - therapy
Female
Genotype
Glasgow Coma Scale
Humans
Male
Middle Aged
People with disabilities
Polymorphism, Genetic - genetics
Predictive Value of Tests
Prognosis
Prospective Studies
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Summary:The prognosis of traumatic brain injury is quite variable and not fully explained by the known factors. This study is to examine if the polymorphism of apolipoprotein E (apoE) influences the outcome of traumatic brain injury. Over a period of twelve months, we prospectively studied 100 patients who sustained traumatic brain injuries and were admitted to our neurosurgical unit. Nineteen patients were apoE4+ and 81 patients were apoE4-. There was no significant difference between apoE4+ and apoE4- groups in the cause of injury (p=0.288), type of brain injury (p=0.983) and choice of treatment (p=0.88). The proportion of patients with a lower GCS (
ISSN:0001-6268
0942-0940
DOI:10.1007/s00701-003-0069-3