Aberrations of chromosome segment 12q13–15 characterize a subgroup of hemangiopericytomas

Background. In later years, several characteristic acquired chromosomal aberrations have been identified in mesenchymal tumors. Many of these aberrations, either alone or with histopathologic and clinical data, are useful in diagnosis. The cytogenetic profile of hemangio‐pericytomas has been poorly...

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Bibliographic Details
Published in:Cancer 1993-05, Vol.71 (10), p.3009-3013
Main Authors: Mandahl, Nils, Örndal, Charlotte, Heim, Sverre, Mitelman, Felix, Willén, Helena, Rydholm, Anders, Bauer, Henrik C. F.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Chromosome Aberrations - pathology
Chromosome Banding
Chromosome Disorders
chromosome rearrangements
Chromosomes, Human, Pair 12
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
hemangiopericytoma
Hemangiopericytoma - genetics
Hemangiopericytoma - pathology
Humans
Male
Medical sciences
Middle Aged
Sarcoma - genetics
Sarcoma - pathology
spindle cell tumor
synovial sarcoma
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Summary:Background. In later years, several characteristic acquired chromosomal aberrations have been identified in mesenchymal tumors. Many of these aberrations, either alone or with histopathologic and clinical data, are useful in diagnosis. The cytogenetic profile of hemangio‐pericytomas has been poorly investigated. Methods. Short‐term cultures from four spindle cell tumors were cytogenetically analyzed. Results. Clonal acquired chromosome aberrations were found in three of the four tumors: inv(12) (q14q24) in a malignant hemangiopericytoma, a supernumerary der(3)t(3;12) (p21–23;q13–15) in a benign hemangiopericytoma, and t(6;12;19) (p21;q13;p13) in a spindle cell sarcoma that was histologically a malignant hemangiopericytoma or a synovial sarcoma. The fourth tumor, a malignant hemangiopericytoma, had a normal karyotype. The tumors with inv(12) and t(6;12;19) had subclones with trisomy 5 in addition to the structural changes. Conclusions. The current findings and the literature data indicate that a subgroup of hemangiopericytomas is characterized by rearrangement of chromosome segment 12q13–15.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19930515)71:10<3009::AID-CNCR2820711020>3.0.CO;2-Y