Postprandial lipemia and cardiovascular disease

Postprandial lipemia, characterized by a rise in triglyceride-rich lipoproteins after eating, is a dynamic, nonsteady-state condition in which humans spend the majority of time. There are several lines of evidence suggesting that postprandial lipemia increases risk of atherogenesis. Clinical data sh...

Full description

Saved in:
Bibliographic Details
Published in:Current atherosclerosis reports 2003-11, Vol.5 (6), p.437-444
Main Authors: Hyson, Dianne, Rutledge, John C, Berglund, Lars
Format: Article
Language:English
Subjects:
Arteriosclerosis - blood
Arteriosclerosis - complications
Arteriosclerosis - etiology
Arteriosclerosis - pathology
Cardiovascular Diseases - blood
Cardiovascular Diseases - etiology
Cardiovascular Diseases - pathology
Carotid Arteries - pathology
Cholesterol, HDL - blood
Clinical Trials as Topic
Humans
Hyperlipoproteinemias - blood
Hyperlipoproteinemias - complications
Hyperlipoproteinemias - pathology
Lipoproteins - blood
Lipoproteins, LDL - blood
Postprandial Period
Risk Factors
Triglycerides - blood
Tunica Intima - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Postprandial lipemia, characterized by a rise in triglyceride-rich lipoproteins after eating, is a dynamic, nonsteady-state condition in which humans spend the majority of time. There are several lines of evidence suggesting that postprandial lipemia increases risk of atherogenesis. Clinical data show a correlation between postprandial lipoproteins and the presence/progression of coronary artery disease and carotid intimal thickness. Mechanistic studies demonstrate that triglyceride-rich lipoprotein remnants may have adverse effects on endothelium and can penetrate into the subendothelial space. Exchange of core lipids between postprandial lipoproteins and low-density lipoprotein (LDL)/high-density lipoprotein (HDL) is increased during prolonged lipemia, resulting in small, dense LDL particles and reduced HDL cholesterol levels. Hemostatic variables, including clotting factors, platelet reactivity, and monocyte cytokine expression, may be increased during postprandial lipemia. Collectively, these data suggest that assessment and treatment of atherosclerosis should include parameters related to postprandial lipemia.
ISSN:1523-3804
1534-6242
DOI:10.1007/s11883-003-0033-y