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Exhaled nitric oxide is age-dependent in asthma
We determined whether the exhaled nitric oxide (eNO) level in asthmatics is age‐dependent. Eighty‐seven asthmatic patients aged 2–41 years were studied. Hyperreactivity to adenosine 5′‐monophosphate (AMP) was used to confirm asthma (≤200 mg/ml). In the younger group of children (2–5 years), AMP chal...
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| Published in: | Pediatric pulmonology 2003-11, Vol.36 (5), p.433-438 |
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| Main Authors: | , , , , , |
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| container_end_page | 438 |
| container_issue | 5 |
| container_start_page | 433 |
| container_title | Pediatric pulmonology |
| container_volume | 36 |
| creator | Avital, Avraham Uwyyed, Kamal Berkman, Neville Bar-Yishay, Ephraim Godfrey, Simon Springer, Chaim |
| description | We determined whether the exhaled nitric oxide (eNO) level in asthmatics is age‐dependent. Eighty‐seven asthmatic patients aged 2–41 years were studied. Hyperreactivity to adenosine 5′‐monophosphate (AMP) was used to confirm asthma (≤200 mg/ml). In the younger group of children (2–5 years), AMP challenge was performed by the provocation concentration causing wheeze (PCW) method, while in the older groups of patients (6–41 years), regular spirometry was used. Exhaled NO was measured in the younger group by the tidal breathing method (TBm) and in the older subjects by the slow vital capacity method (SVCm). TBm and SVCm were compared in 21 other subjects, and there was a significant correlation between the two values (r = 0.96, P |
| doi_str_mv | 10.1002/ppul.10377 |
| format | article |
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Eighty‐seven asthmatic patients aged 2–41 years were studied. Hyperreactivity to adenosine 5′‐monophosphate (AMP) was used to confirm asthma (≤200 mg/ml). In the younger group of children (2–5 years), AMP challenge was performed by the provocation concentration causing wheeze (PCW) method, while in the older groups of patients (6–41 years), regular spirometry was used. Exhaled NO was measured in the younger group by the tidal breathing method (TBm) and in the older subjects by the slow vital capacity method (SVCm). TBm and SVCm were compared in 21 other subjects, and there was a significant correlation between the two values (r = 0.96, P < 0.0001). The equation of correlation between the two methods was eNOTBm = 0.78eNOSVCm − 0.51. Within asthmatic patients, we found a significant increase in eNO with age (P < 0.0001), while there was no significant difference in AMP reactivity (P = 0.35). We conclude that eNO in asthmatic patients is age‐dependent, with lower values in young children. Pediatr Pulmonol. 2003; 36:433–438. © 2003 Wiley‐Liss, Inc.</description><identifier>ISSN: 8755-6863</identifier><identifier>EISSN: 1099-0496</identifier><identifier>DOI: 10.1002/ppul.10377</identifier><identifier>PMID: 14520727</identifier><identifier>CODEN: PEPUES</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>adenosine 5′-monophosphate ; Adenosine Monophosphate ; Adolescent ; Adult ; age ; Age Factors ; asthma ; Asthma - diagnosis ; Asthma - metabolism ; Biological and medical sciences ; Breath Tests - methods ; Bronchial Provocation Tests - methods ; Child ; Child, Preschool ; exhaled nitric oxide ; Female ; Humans ; Investigative techniques of respiratory function ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Nitric Oxide - metabolism ; Respiratory Function Tests - methods ; Sex Factors</subject><ispartof>Pediatric pulmonology, 2003-11, Vol.36 (5), p.433-438</ispartof><rights>Copyright © 2003 Wiley‐Liss, Inc.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 Wiley-Liss, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3937-cf7a0d30b3e4e52858fd8d8ab03ef826782069fb0d04dca084bbcf03b52d0c5d3</citedby><cites>FETCH-LOGICAL-c3937-cf7a0d30b3e4e52858fd8d8ab03ef826782069fb0d04dca084bbcf03b52d0c5d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15232691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14520727$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Avital, Avraham</creatorcontrib><creatorcontrib>Uwyyed, Kamal</creatorcontrib><creatorcontrib>Berkman, Neville</creatorcontrib><creatorcontrib>Bar-Yishay, Ephraim</creatorcontrib><creatorcontrib>Godfrey, Simon</creatorcontrib><creatorcontrib>Springer, Chaim</creatorcontrib><title>Exhaled nitric oxide is age-dependent in asthma</title><title>Pediatric pulmonology</title><addtitle>Pediatr. Pulmonol</addtitle><description>We determined whether the exhaled nitric oxide (eNO) level in asthmatics is age‐dependent. Eighty‐seven asthmatic patients aged 2–41 years were studied. Hyperreactivity to adenosine 5′‐monophosphate (AMP) was used to confirm asthma (≤200 mg/ml). In the younger group of children (2–5 years), AMP challenge was performed by the provocation concentration causing wheeze (PCW) method, while in the older groups of patients (6–41 years), regular spirometry was used. Exhaled NO was measured in the younger group by the tidal breathing method (TBm) and in the older subjects by the slow vital capacity method (SVCm). TBm and SVCm were compared in 21 other subjects, and there was a significant correlation between the two values (r = 0.96, P < 0.0001). The equation of correlation between the two methods was eNOTBm = 0.78eNOSVCm − 0.51. Within asthmatic patients, we found a significant increase in eNO with age (P < 0.0001), while there was no significant difference in AMP reactivity (P = 0.35). We conclude that eNO in asthmatic patients is age‐dependent, with lower values in young children. Pediatr Pulmonol. 2003; 36:433–438. © 2003 Wiley‐Liss, Inc.</description><subject>adenosine 5′-monophosphate</subject><subject>Adenosine Monophosphate</subject><subject>Adolescent</subject><subject>Adult</subject><subject>age</subject><subject>Age Factors</subject><subject>asthma</subject><subject>Asthma - diagnosis</subject><subject>Asthma - metabolism</subject><subject>Biological and medical sciences</subject><subject>Breath Tests - methods</subject><subject>Bronchial Provocation Tests - methods</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>exhaled nitric oxide</subject><subject>Female</subject><subject>Humans</subject><subject>Investigative techniques of respiratory function</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nitric Oxide - metabolism</subject><subject>Respiratory Function Tests - methods</subject><subject>Sex Factors</subject><issn>8755-6863</issn><issn>1099-0496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp90EtPwzAMB_AIgWAMLnwA1AsckApuHk16hGk8pAFDvI5RmrgQ6LrSdGJ8ewobcONkS_7Zlv6E7CRwmADQo7qelV3HpFwhvQSyLAaepaukp6QQcapStkE2Q3gB6GZZsk42Ei4oSCp75Gg4fzYluqjybeNtNJ17h5EPkXnC2GGNlcOqjXwVmdA-T8wWWStMGXB7Wfvk_nR4NziPR9dnF4PjUWxZxmRsC2nAMcgZchRUCVU45ZTJgWGhaCoVhTQrcnDAnTWgeJ7bAlguqAMrHOuT_cXdupm-zTC0euKDxbI0FU5nQUshGeOcd_BgAW0zDaHBQteNn5jmQyegv-LRX_Ho73g6vLu8Ossn6P7oMo8O7C2BCdaURWMq68OfE5TRNEs6lyzcuy_x45-Xejy-H_08jxc7PrQ4_90xzatOJZNCP16d6Uv1cHJ7M-D6hn0CWg-LRw</recordid><startdate>200311</startdate><enddate>200311</enddate><creator>Avital, Avraham</creator><creator>Uwyyed, Kamal</creator><creator>Berkman, Neville</creator><creator>Bar-Yishay, Ephraim</creator><creator>Godfrey, Simon</creator><creator>Springer, Chaim</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200311</creationdate><title>Exhaled nitric oxide is age-dependent in asthma</title><author>Avital, Avraham ; Uwyyed, Kamal ; Berkman, Neville ; Bar-Yishay, Ephraim ; Godfrey, Simon ; Springer, Chaim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3937-cf7a0d30b3e4e52858fd8d8ab03ef826782069fb0d04dca084bbcf03b52d0c5d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>adenosine 5′-monophosphate</topic><topic>Adenosine Monophosphate</topic><topic>Adolescent</topic><topic>Adult</topic><topic>age</topic><topic>Age Factors</topic><topic>asthma</topic><topic>Asthma - diagnosis</topic><topic>Asthma - metabolism</topic><topic>Biological and medical sciences</topic><topic>Breath Tests - methods</topic><topic>Bronchial Provocation Tests - methods</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>exhaled nitric oxide</topic><topic>Female</topic><topic>Humans</topic><topic>Investigative techniques of respiratory function</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nitric Oxide - metabolism</topic><topic>Respiratory Function Tests - methods</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avital, Avraham</creatorcontrib><creatorcontrib>Uwyyed, Kamal</creatorcontrib><creatorcontrib>Berkman, Neville</creatorcontrib><creatorcontrib>Bar-Yishay, Ephraim</creatorcontrib><creatorcontrib>Godfrey, Simon</creatorcontrib><creatorcontrib>Springer, Chaim</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric pulmonology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avital, Avraham</au><au>Uwyyed, Kamal</au><au>Berkman, Neville</au><au>Bar-Yishay, Ephraim</au><au>Godfrey, Simon</au><au>Springer, Chaim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exhaled nitric oxide is age-dependent in asthma</atitle><jtitle>Pediatric pulmonology</jtitle><addtitle>Pediatr. Pulmonol</addtitle><date>2003-11</date><risdate>2003</risdate><volume>36</volume><issue>5</issue><spage>433</spage><epage>438</epage><pages>433-438</pages><issn>8755-6863</issn><eissn>1099-0496</eissn><coden>PEPUES</coden><abstract>We determined whether the exhaled nitric oxide (eNO) level in asthmatics is age‐dependent. Eighty‐seven asthmatic patients aged 2–41 years were studied. Hyperreactivity to adenosine 5′‐monophosphate (AMP) was used to confirm asthma (≤200 mg/ml). In the younger group of children (2–5 years), AMP challenge was performed by the provocation concentration causing wheeze (PCW) method, while in the older groups of patients (6–41 years), regular spirometry was used. Exhaled NO was measured in the younger group by the tidal breathing method (TBm) and in the older subjects by the slow vital capacity method (SVCm). TBm and SVCm were compared in 21 other subjects, and there was a significant correlation between the two values (r = 0.96, P < 0.0001). The equation of correlation between the two methods was eNOTBm = 0.78eNOSVCm − 0.51. Within asthmatic patients, we found a significant increase in eNO with age (P < 0.0001), while there was no significant difference in AMP reactivity (P = 0.35). We conclude that eNO in asthmatic patients is age‐dependent, with lower values in young children. Pediatr Pulmonol. 2003; 36:433–438. © 2003 Wiley‐Liss, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>14520727</pmid><doi>10.1002/ppul.10377</doi><tpages>6</tpages></addata></record> |
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| subjects | adenosine 5′-monophosphate Adenosine Monophosphate Adolescent Adult age Age Factors asthma Asthma - diagnosis Asthma - metabolism Biological and medical sciences Breath Tests - methods Bronchial Provocation Tests - methods Child Child, Preschool exhaled nitric oxide Female Humans Investigative techniques of respiratory function Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Nitric Oxide - metabolism Respiratory Function Tests - methods Sex Factors |
| title | Exhaled nitric oxide is age-dependent in asthma |
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