Plasma Concentrations of Aminoterminal Pro Atrial Natriuretic Peptide and Aminoterminal Pro Brain Natriuretic Peptide in Healthy Neonates: Marked and Rapid Increase After Birth

The purpose of the study was to examine the possible age dependency of plasma N-terminal pro atrial natriuretic peptide (N-ANP) and N-terminal pro brain natriuretic peptide (N-BNP) levels in healthy term neonates to establish normal ranges for the neonatal period. N-ANP and N-BNP plasma concentratio...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2003-10, Vol.112 (4), p.896-899
Main Authors: Mir, Thomas S, Laux, Reinhard, Hellwege, Hans Henning, Liedke, Bozena, Heinze, Cornelius, von Buelow, Helmut, Laer, Stephanie, Weil, Jochen
Format: Article
Language:English
Subjects:
Atrial Natriuretic Factor - blood
Biological and medical sciences
Blood plasma
Brain
Care and treatment
Composition
Diseases
Female
Fetal Blood - chemistry
General aspects
Health aspects
Humans
Immunoassay
Immunoenzyme technique
Immunoenzyme techniques
Infant, Newborn - blood
Infants (Newborn)
Male
Medical sciences
Natriuretic Peptide, Brain
Natriuretic peptides
Neonatal diseases
Nerve Tissue Proteins - blood
Newborn infants
Pediatrics
Peptide Fragments - blood
Peptides
Physiological aspects
Plasma
Prenatal development
Protein Precursors - blood
Reference Values
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Summary:The purpose of the study was to examine the possible age dependency of plasma N-terminal pro atrial natriuretic peptide (N-ANP) and N-terminal pro brain natriuretic peptide (N-BNP) levels in healthy term neonates to establish normal ranges for the neonatal period. N-ANP and N-BNP plasma concentrations were measured in peripheral venous (n = 116) and umbilical cord blood (n = 37) in 153 healthy term neonates (mean: 5.1; range: 0-30 days) using an enzyme immunoassay. The neonates were classified into 8 groups according to their age (day of delivery and 1, 2, 3, 4, 5-7, 8-14, and 14-30 days of age). The plasma N-ANP and N-BNP concentration were the highest at the first day of age (96 700; 6912-436 000 and 641; 254-1272 fmol/mL) and were found significantly higher compared with the day of delivery (5680; 1005-16 900 and 221; 58-478 fmol/mL; P < 0,0001). After this marked increase, N-ANP and N-BNP levels decreased steadily and became stable at the fifth (5232; 2691-7353 fmol/mL) and third (246; 110-430 fmol/mL) day of life, respectively. The N-ANP and N-BNP plasma concentrations in healthy neonates showed a marked increase during the first days of age, suggesting that ANP and BNP have physiologic roles in the perinatal circulatory change from fetus to neonate.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.112.4.896