Effect of oesophageal acid instillation on coronary blood flow

To assess whether gastrointestinal factors can cause chest pain ("linked angina"), we studied the effect of oesophageal stimulation with acid on coronary blood flow in 20 syndrome X patients. Coronary blood flow velocity (CBFV) was measured with an intracoronary doppler catheter positioned...

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Bibliographic Details
Published in:The Lancet (British edition) 1993-05, Vol.341 (8856), p.1309-1310
Main Authors: Chauhan, A., Petch, M.C., Schofield, P.M.
Format: Article
Language:English
Subjects:
Adult
Aged
Angina pectoris
Angina Pectoris - etiology
Angina Pectoris - physiopathology
Blood Flow Velocity
Coronary Circulation - physiology
Digestive system
Esophagus - physiopathology
Female
Gastric Acid - physiology
Gastroesophageal Reflux - complications
Humans
Male
Medical instruments
Medical research
Middle Aged
Pain
Syndrome
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Summary:To assess whether gastrointestinal factors can cause chest pain ("linked angina"), we studied the effect of oesophageal stimulation with acid on coronary blood flow in 20 syndrome X patients. Coronary blood flow velocity (CBFV) was measured with an intracoronary doppler catheter positioned in the proximal left anterior descending coronary artery. Acid stimulation produced typical anginal pain in 11 patients. Mean CBFV was significantly reduced from 7·3 (SD 4·0) to 4·4 (2·8) cm/s. Gastro-oesophageal reflux leading to reduced coronary blood flow may be a mechanism to explain linked angina.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(93)90817-Z