Studies on the Antioxidant Activities of Desmodium gangeticum

Desmodium gangeticum is herbal species which is widely used in the indigenous system of medicine and is reported to contain flavone and isoflavanoid glycosides. In view of its wide use and it's chemical composition, this study was aimed at examining the antioxidant activity of the extract of D....

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Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2003, Vol.26(10), pp.1424-1427
Main Authors: Govindarajan, Raghavan, Rastogi, Subha, Vijayakumar, Madhavan, Shirwaikar, Annie, Rawat, Ajay Kumar Singh, Mehrotra, Shanta, Pushpangadan, Palpu
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Animals
Antioxidants - isolation & purification
Antioxidants - pharmacology
Biological and medical sciences
Brain - drug effects
Brain - metabolism
Desmodium gangeticum
diphenyl picryl hydrazyl (DPPH)
Fabaceae
ferryl-bipyridyl
Free Radical Scavengers - metabolism
Fundamental and applied biological sciences. Psychology
General pharmacology
hypochlorous acid
lipid peroxidation
Male
Medical sciences
nitric oxide
Pharmacology. Drug treatments
Plant Components, Aerial
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Rats
Rats, Sprague-Dawley
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Summary:Desmodium gangeticum is herbal species which is widely used in the indigenous system of medicine and is reported to contain flavone and isoflavanoid glycosides. In view of its wide use and it's chemical composition, this study was aimed at examining the antioxidant activity of the extract of D. gangeticum. The extract was studied for diphenyl picryl hydrazyl (DPPH), nitric oxide, ferryl-bipyridyl and hypochlorous acid scavenging activity along with lipid peroxidation. Nitric oxide was generated using sodium nitroprusside and was studied using Griess reagent. In order to study the iron chelating capacity of the extract, the percentage ferryl-bipyridyl inhibition was studied. Hypochlorous acid scavenging activity was tested by measuring the inhibition of 5-thio-2-nitrobenzoic acid oxidation. The extract was also studied for lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat brain homogenate. The results indicate that D. gangeticum extract has potent antioxidant activity.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.26.1424