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Studies on the Antioxidant Activities of Desmodium gangeticum
Desmodium gangeticum is herbal species which is widely used in the indigenous system of medicine and is reported to contain flavone and isoflavanoid glycosides. In view of its wide use and it's chemical composition, this study was aimed at examining the antioxidant activity of the extract of D....
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| Published in: | Biological & Pharmaceutical Bulletin 2003, Vol.26(10), pp.1424-1427 |
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| Main Authors: | , , , , , , |
| Format: | Article |
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| cites | cdi_FETCH-LOGICAL-c719t-ad8f5a2eee410c1493d8b5d7c2604e57031f7d23933cfc49b056b1c3d70d3743 |
| container_end_page | 1427 |
| container_issue | 10 |
| container_start_page | 1424 |
| container_title | Biological & Pharmaceutical Bulletin |
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| creator | Govindarajan, Raghavan Rastogi, Subha Vijayakumar, Madhavan Shirwaikar, Annie Rawat, Ajay Kumar Singh Mehrotra, Shanta Pushpangadan, Palpu |
| description | Desmodium gangeticum is herbal species which is widely used in the indigenous system of medicine and is reported to contain flavone and isoflavanoid glycosides. In view of its wide use and it's chemical composition, this study was aimed at examining the antioxidant activity of the extract of D. gangeticum. The extract was studied for diphenyl picryl hydrazyl (DPPH), nitric oxide, ferryl-bipyridyl and hypochlorous acid scavenging activity along with lipid peroxidation. Nitric oxide was generated using sodium nitroprusside and was studied using Griess reagent. In order to study the iron chelating capacity of the extract, the percentage ferryl-bipyridyl inhibition was studied. Hypochlorous acid scavenging activity was tested by measuring the inhibition of 5-thio-2-nitrobenzoic acid oxidation. The extract was also studied for lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat brain homogenate. The results indicate that D. gangeticum extract has potent antioxidant activity. |
| doi_str_mv | 10.1248/bpb.26.1424 |
| format | article |
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In view of its wide use and it's chemical composition, this study was aimed at examining the antioxidant activity of the extract of D. gangeticum. The extract was studied for diphenyl picryl hydrazyl (DPPH), nitric oxide, ferryl-bipyridyl and hypochlorous acid scavenging activity along with lipid peroxidation. Nitric oxide was generated using sodium nitroprusside and was studied using Griess reagent. In order to study the iron chelating capacity of the extract, the percentage ferryl-bipyridyl inhibition was studied. Hypochlorous acid scavenging activity was tested by measuring the inhibition of 5-thio-2-nitrobenzoic acid oxidation. The extract was also studied for lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat brain homogenate. The results indicate that D. gangeticum extract has potent antioxidant activity.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.26.1424</identifier><identifier>PMID: 14519948</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Analysis ; Analytical, structural and metabolic biochemistry ; Animals ; Antioxidants - isolation & purification ; Antioxidants - pharmacology ; Biological and medical sciences ; Brain - drug effects ; Brain - metabolism ; Desmodium gangeticum ; diphenyl picryl hydrazyl (DPPH) ; Fabaceae ; ferryl-bipyridyl ; Free Radical Scavengers - metabolism ; Fundamental and applied biological sciences. Psychology ; General pharmacology ; hypochlorous acid ; lipid peroxidation ; Male ; Medical sciences ; nitric oxide ; Pharmacology. Drug treatments ; Plant Components, Aerial ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Rats ; Rats, Sprague-Dawley</subject><ispartof>Biological and Pharmaceutical Bulletin, 2003, Vol.26(10), pp.1424-1427</ispartof><rights>2003 The Pharmaceutical Society of Japan</rights><rights>2004 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c719t-ad8f5a2eee410c1493d8b5d7c2604e57031f7d23933cfc49b056b1c3d70d3743</citedby><cites>FETCH-LOGICAL-c719t-ad8f5a2eee410c1493d8b5d7c2604e57031f7d23933cfc49b056b1c3d70d3743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15280830$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14519948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Govindarajan, Raghavan</creatorcontrib><creatorcontrib>Rastogi, Subha</creatorcontrib><creatorcontrib>Vijayakumar, Madhavan</creatorcontrib><creatorcontrib>Shirwaikar, Annie</creatorcontrib><creatorcontrib>Rawat, Ajay Kumar Singh</creatorcontrib><creatorcontrib>Mehrotra, Shanta</creatorcontrib><creatorcontrib>Pushpangadan, Palpu</creatorcontrib><creatorcontrib>College of Pharmaceutical Sciences</creatorcontrib><creatorcontrib>aPharmacognosy and Ethnopharmacology Division</creatorcontrib><creatorcontrib>bPhamacognosy Department</creatorcontrib><creatorcontrib>National Botanical Research Institute</creatorcontrib><title>Studies on the Antioxidant Activities of Desmodium gangeticum</title><title>Biological & Pharmaceutical Bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>Desmodium gangeticum is herbal species which is widely used in the indigenous system of medicine and is reported to contain flavone and isoflavanoid glycosides. In view of its wide use and it's chemical composition, this study was aimed at examining the antioxidant activity of the extract of D. gangeticum. The extract was studied for diphenyl picryl hydrazyl (DPPH), nitric oxide, ferryl-bipyridyl and hypochlorous acid scavenging activity along with lipid peroxidation. Nitric oxide was generated using sodium nitroprusside and was studied using Griess reagent. In order to study the iron chelating capacity of the extract, the percentage ferryl-bipyridyl inhibition was studied. Hypochlorous acid scavenging activity was tested by measuring the inhibition of 5-thio-2-nitrobenzoic acid oxidation. The extract was also studied for lipid peroxidation assay by thiobarbituric acid-reactive substances (TBARS) method using rat brain homogenate. The results indicate that D. gangeticum extract has potent antioxidant activity.</description><subject>Analysis</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Antioxidants - isolation & purification</subject><subject>Antioxidants - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Desmodium gangeticum</subject><subject>diphenyl picryl hydrazyl (DPPH)</subject><subject>Fabaceae</subject><subject>ferryl-bipyridyl</subject><subject>Free Radical Scavengers - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>General pharmacology</subject><subject>hypochlorous acid</subject><subject>lipid peroxidation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>nitric oxide</subject><subject>Pharmacology. Drug treatments</subject><subject>Plant Components, Aerial</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><issn>0918-6158</issn><issn>1347-5215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNpdkc9v0zAYhi0EYmVw4o4iIXZBKZ9_xcmBQxkwkCZxYHfLsZ3OVWIX20Hw389twypx-Xzwo_d7_Bqh1xjWmLD2Q7_v16RZY0bYE7TClImaE8yfohV0uK0bzNsL9CKlHQAIIPQ5usCM465j7Qp9_Jln42yqgq_yva02Prvwxxnlc7XR2f12-Xg7VJ9tmoJx81Rtld_a7PQ8vUTPBjUm-2o5L9Hd1y9319_q2x833683t7UWuMu1Mu3AFbHWMgwas46atudGaNIAs1wAxYMwhHaU6kGzrgfe9FhTI8BQweglujrF7mP4NduU5eSStuOovA1zkoKL8ngqCvj2P3AX5uiLmsSsrIWGUVKo9ydKx5BStIPcRzep-FdikIdKZalUkkYeKi30myVz7idrzuzSYQHeLYBKWo1DVF67dOY4aaGlULibE1dSXAGDH523Z0OdRO_CGCQBoBKANEUHMD5qHIbAIATvDkqfTkm7lNXWPq5SsfzKaB_1YZnHgH-X-l5FaT19ACoJqpU</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Govindarajan, Raghavan</creator><creator>Rastogi, Subha</creator><creator>Vijayakumar, Madhavan</creator><creator>Shirwaikar, Annie</creator><creator>Rawat, Ajay Kumar Singh</creator><creator>Mehrotra, Shanta</creator><creator>Pushpangadan, Palpu</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><general>Maruzen</general><general>Japan Science and Technology Agency</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Studies on the Antioxidant Activities of Desmodium gangeticum</title><author>Govindarajan, Raghavan ; Rastogi, Subha ; Vijayakumar, Madhavan ; Shirwaikar, Annie ; Rawat, Ajay Kumar Singh ; Mehrotra, Shanta ; Pushpangadan, Palpu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c719t-ad8f5a2eee410c1493d8b5d7c2604e57031f7d23933cfc49b056b1c3d70d3743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Analysis</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Animals</topic><topic>Antioxidants - isolation & purification</topic><topic>Antioxidants - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Desmodium gangeticum</topic><topic>diphenyl picryl hydrazyl (DPPH)</topic><topic>Fabaceae</topic><topic>ferryl-bipyridyl</topic><topic>Free Radical Scavengers - metabolism</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Biological and Pharmaceutical Bulletin, 2003, Vol.26(10), pp.1424-1427 |
| issn | 0918-6158 1347-5215 |
| language | eng |
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| source | Free Full-Text Journals in Chemistry |
| subjects | Analysis Analytical, structural and metabolic biochemistry Animals Antioxidants - isolation & purification Antioxidants - pharmacology Biological and medical sciences Brain - drug effects Brain - metabolism Desmodium gangeticum diphenyl picryl hydrazyl (DPPH) Fabaceae ferryl-bipyridyl Free Radical Scavengers - metabolism Fundamental and applied biological sciences. Psychology General pharmacology hypochlorous acid lipid peroxidation Male Medical sciences nitric oxide Pharmacology. Drug treatments Plant Components, Aerial Plant Extracts - isolation & purification Plant Extracts - pharmacology Rats Rats, Sprague-Dawley |
| title | Studies on the Antioxidant Activities of Desmodium gangeticum |
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