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Percutaneous Aspiration-Injection-Reaspiration Drainage Plus Albendazole or Mebendazole for Hepatic Cystic Echinococcosis: A Meta-analysis
Using meta-analysis methodology, we compared the clinical outcomes for 769 patients with hepatic cystic echinococcosis treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole or mebendazole (group 1) with 952 era-matched historical control subjects undergoing surgical int...
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| Published in: | Clinical infectious diseases 2003-10, Vol.37 (8), p.1073-1083 |
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| cited_by | cdi_FETCH-LOGICAL-c517t-8d935854b33e437f202a50564be5cffe270b6ace54ced455452b551e68671fb93 |
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| cites | cdi_FETCH-LOGICAL-c517t-8d935854b33e437f202a50564be5cffe270b6ace54ced455452b551e68671fb93 |
| container_end_page | 1083 |
| container_issue | 8 |
| container_start_page | 1073 |
| container_title | Clinical infectious diseases |
| container_volume | 37 |
| creator | Smego, Raymond A. Bhatti, Sabha Khaliq, Amir A. Beg, M. Asim |
| description | Using meta-analysis methodology, we compared the clinical outcomes for 769 patients with hepatic cystic echinococcosis treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole or mebendazole (group 1) with 952 era-matched historical control subjects undergoing surgical intervention (group 2). The rate of clinical and parasitologic cure (P < .0001) was greater in patients receiving PAIR plus chemotherapy. Disease recurrence (P < .0001), major complications (anaphylaxis, biliary fistula, cyst infection, liver/intra-abdominal abscess, and sepsis; P < .0001), minor complications (P < .0001), and death (P < .0824) occurred more frequently among surgical control subjects. Fever (P < .002) and minor allergic reactions subjects (P < .0001) were more common among PAIR-treated subjects. The mean durations of hospital stay were 2.4 days for group 1 and 15.0 days for group 2 (P < .001). Compared with surgery, PAIR plus chemotherapy is associated with greater clinical and parasitologic efficacy; lower rates of morbidity, mortality, and disease recurrence; and shorter hospital stays. |
| doi_str_mv | 10.1086/378275 |
| format | article |
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Asim</creator><creatorcontrib>Smego, Raymond A. ; Bhatti, Sabha ; Khaliq, Amir A. ; Beg, M. Asim</creatorcontrib><description><![CDATA[Using meta-analysis methodology, we compared the clinical outcomes for 769 patients with hepatic cystic echinococcosis treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole or mebendazole (group 1) with 952 era-matched historical control subjects undergoing surgical intervention (group 2). The rate of clinical and parasitologic cure (P < .0001) was greater in patients receiving PAIR plus chemotherapy. Disease recurrence (P < .0001), major complications (anaphylaxis, biliary fistula, cyst infection, liver/intra-abdominal abscess, and sepsis; P < .0001), minor complications (P < .0001), and death (P < .0824) occurred more frequently among surgical control subjects. Fever (P < .002) and minor allergic reactions subjects (P < .0001) were more common among PAIR-treated subjects. The mean durations of hospital stay were 2.4 days for group 1 and 15.0 days for group 2 (P < .001). Compared with surgery, PAIR plus chemotherapy is associated with greater clinical and parasitologic efficacy; lower rates of morbidity, mortality, and disease recurrence; and shorter hospital stays.]]></description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/378275</identifier><identifier>PMID: 14523772</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Albendazole - therapeutic use ; Anaphylaxis ; Animals ; Anthelmintics - therapeutic use ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiparasitic agents ; Biliary fistula ; Biological and medical sciences ; Cysts ; Diseases caused by cestodes ; Drainage ; Echinococcoses ; Echinococcosis ; Echinococcosis, Hepatic - complications ; Echinococcosis, Hepatic - drug therapy ; Echinococcosis, Hepatic - surgery ; Echinococcus - drug effects ; Ethanol ; Fever ; Health outcomes ; Helminthic diseases ; Humans ; Hydatids ; Infections ; Infectious diseases ; Injections ; Length of Stay ; Liver ; Major Articles ; Mebendazole - therapeutic use ; Medical sciences ; Parasitic diseases ; Pharmacology. Drug treatments ; Recurrence ; Treatment Outcome</subject><ispartof>Clinical infectious diseases, 2003-10, Vol.37 (8), p.1073-1083</ispartof><rights>Copyright 2003 The Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c517t-8d935854b33e437f202a50564be5cffe270b6ace54ced455452b551e68671fb93</citedby><cites>FETCH-LOGICAL-c517t-8d935854b33e437f202a50564be5cffe270b6ace54ced455452b551e68671fb93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/4483621$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/4483621$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15235400$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14523772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Smego, Raymond A.</creatorcontrib><creatorcontrib>Bhatti, Sabha</creatorcontrib><creatorcontrib>Khaliq, Amir A.</creatorcontrib><creatorcontrib>Beg, M. Asim</creatorcontrib><title>Percutaneous Aspiration-Injection-Reaspiration Drainage Plus Albendazole or Mebendazole for Hepatic Cystic Echinococcosis: A Meta-analysis</title><title>Clinical infectious diseases</title><addtitle>Clinical Infectious Diseases</addtitle><addtitle>Clinical Infectious Diseases</addtitle><description><![CDATA[Using meta-analysis methodology, we compared the clinical outcomes for 769 patients with hepatic cystic echinococcosis treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole or mebendazole (group 1) with 952 era-matched historical control subjects undergoing surgical intervention (group 2). The rate of clinical and parasitologic cure (P < .0001) was greater in patients receiving PAIR plus chemotherapy. Disease recurrence (P < .0001), major complications (anaphylaxis, biliary fistula, cyst infection, liver/intra-abdominal abscess, and sepsis; P < .0001), minor complications (P < .0001), and death (P < .0824) occurred more frequently among surgical control subjects. Fever (P < .002) and minor allergic reactions subjects (P < .0001) were more common among PAIR-treated subjects. The mean durations of hospital stay were 2.4 days for group 1 and 15.0 days for group 2 (P < .001). Compared with surgery, PAIR plus chemotherapy is associated with greater clinical and parasitologic efficacy; lower rates of morbidity, mortality, and disease recurrence; and shorter hospital stays.]]></description><subject>Albendazole - therapeutic use</subject><subject>Anaphylaxis</subject><subject>Animals</subject><subject>Anthelmintics - therapeutic use</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiparasitic agents</subject><subject>Biliary fistula</subject><subject>Biological and medical sciences</subject><subject>Cysts</subject><subject>Diseases caused by cestodes</subject><subject>Drainage</subject><subject>Echinococcoses</subject><subject>Echinococcosis</subject><subject>Echinococcosis, Hepatic - complications</subject><subject>Echinococcosis, Hepatic - drug therapy</subject><subject>Echinococcosis, Hepatic - surgery</subject><subject>Echinococcus - drug effects</subject><subject>Ethanol</subject><subject>Fever</subject><subject>Health outcomes</subject><subject>Helminthic diseases</subject><subject>Humans</subject><subject>Hydatids</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Injections</subject><subject>Length of Stay</subject><subject>Liver</subject><subject>Major Articles</subject><subject>Mebendazole - therapeutic use</subject><subject>Medical sciences</subject><subject>Parasitic diseases</subject><subject>Pharmacology. Drug treatments</subject><subject>Recurrence</subject><subject>Treatment Outcome</subject><issn>1058-4838</issn><issn>1537-6591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNp1kc9u1DAQxi1ERUuBJ6hQOMAtxY49sZfbamm7lVpRAZUqLpbjnRQv2TjYidTtI_DU9Tar3ROn-fP9Zkb-TMg7Rk8ZVeVnLlUh4QU5YsBlXsKEvUw5BZULxdUheR3jklLGFIVX5JAJKLiUxRH5d4PBDr1p0Q8xm8bOBdM73-aX7RLtc_Ydza6dfQ3GteYes5tmwzcVtgvz6BvMfMiucV_WqZ5jl6ZsNlvHTTizv13rrbfWRxe_ZNM00JvctKZZp8YbclCbJuLbbTwmt-dnP2fz_OrbxeVsepVbYLLP1WLCQYGoOEfBZV3QwgCFUlQItq6xkLQqjUUQFhcCID21AmBYqlKyuprwY_Jp3NsF_3fA2OuVixabZjRBS5Bic2EP2uBjDFjrLriVCWvNqN64rkfXE_h-u3GoVrjYY1ubE_BxC5hoTVMH01oX91zCQFCauA8j54fu_8dORmYZex92lEj_XBYsyfkou9jjw0424Y8uJZeg53e_NGUTXsC10j_4E8LxrQY</recordid><startdate>20031015</startdate><enddate>20031015</enddate><creator>Smego, Raymond A.</creator><creator>Bhatti, Sabha</creator><creator>Khaliq, Amir A.</creator><creator>Beg, M. Asim</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031015</creationdate><title>Percutaneous Aspiration-Injection-Reaspiration Drainage Plus Albendazole or Mebendazole for Hepatic Cystic Echinococcosis: A Meta-analysis</title><author>Smego, Raymond A. ; Bhatti, Sabha ; Khaliq, Amir A. ; Beg, M. Asim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c517t-8d935854b33e437f202a50564be5cffe270b6ace54ced455452b551e68671fb93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Albendazole - therapeutic use</topic><topic>Anaphylaxis</topic><topic>Animals</topic><topic>Anthelmintics - therapeutic use</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antiparasitic agents</topic><topic>Biliary fistula</topic><topic>Biological and medical sciences</topic><topic>Cysts</topic><topic>Diseases caused by cestodes</topic><topic>Drainage</topic><topic>Echinococcoses</topic><topic>Echinococcosis</topic><topic>Echinococcosis, Hepatic - complications</topic><topic>Echinococcosis, Hepatic - drug therapy</topic><topic>Echinococcosis, Hepatic - surgery</topic><topic>Echinococcus - drug effects</topic><topic>Ethanol</topic><topic>Fever</topic><topic>Health outcomes</topic><topic>Helminthic diseases</topic><topic>Humans</topic><topic>Hydatids</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Injections</topic><topic>Length of Stay</topic><topic>Liver</topic><topic>Major Articles</topic><topic>Mebendazole - therapeutic use</topic><topic>Medical sciences</topic><topic>Parasitic diseases</topic><topic>Pharmacology. Drug treatments</topic><topic>Recurrence</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Smego, Raymond A.</creatorcontrib><creatorcontrib>Bhatti, Sabha</creatorcontrib><creatorcontrib>Khaliq, Amir A.</creatorcontrib><creatorcontrib>Beg, M. Asim</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Smego, Raymond A.</au><au>Bhatti, Sabha</au><au>Khaliq, Amir A.</au><au>Beg, M. Asim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Percutaneous Aspiration-Injection-Reaspiration Drainage Plus Albendazole or Mebendazole for Hepatic Cystic Echinococcosis: A Meta-analysis</atitle><jtitle>Clinical infectious diseases</jtitle><stitle>Clinical Infectious Diseases</stitle><addtitle>Clinical Infectious Diseases</addtitle><date>2003-10-15</date><risdate>2003</risdate><volume>37</volume><issue>8</issue><spage>1073</spage><epage>1083</epage><pages>1073-1083</pages><issn>1058-4838</issn><eissn>1537-6591</eissn><coden>CIDIEL</coden><abstract><![CDATA[Using meta-analysis methodology, we compared the clinical outcomes for 769 patients with hepatic cystic echinococcosis treated with percutaneous aspiration-injection-reaspiration (PAIR) plus albendazole or mebendazole (group 1) with 952 era-matched historical control subjects undergoing surgical intervention (group 2). The rate of clinical and parasitologic cure (P < .0001) was greater in patients receiving PAIR plus chemotherapy. Disease recurrence (P < .0001), major complications (anaphylaxis, biliary fistula, cyst infection, liver/intra-abdominal abscess, and sepsis; P < .0001), minor complications (P < .0001), and death (P < .0824) occurred more frequently among surgical control subjects. Fever (P < .002) and minor allergic reactions subjects (P < .0001) were more common among PAIR-treated subjects. The mean durations of hospital stay were 2.4 days for group 1 and 15.0 days for group 2 (P < .001). Compared with surgery, PAIR plus chemotherapy is associated with greater clinical and parasitologic efficacy; lower rates of morbidity, mortality, and disease recurrence; and shorter hospital stays.]]></abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>14523772</pmid><doi>10.1086/378275</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | Albendazole - therapeutic use Anaphylaxis Animals Anthelmintics - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Biliary fistula Biological and medical sciences Cysts Diseases caused by cestodes Drainage Echinococcoses Echinococcosis Echinococcosis, Hepatic - complications Echinococcosis, Hepatic - drug therapy Echinococcosis, Hepatic - surgery Echinococcus - drug effects Ethanol Fever Health outcomes Helminthic diseases Humans Hydatids Infections Infectious diseases Injections Length of Stay Liver Major Articles Mebendazole - therapeutic use Medical sciences Parasitic diseases Pharmacology. Drug treatments Recurrence Treatment Outcome |
| title | Percutaneous Aspiration-Injection-Reaspiration Drainage Plus Albendazole or Mebendazole for Hepatic Cystic Echinococcosis: A Meta-analysis |
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