METABOLIC EFFECTS OF PROPOFOL AND FLUNITRAZEPAM GIVEN FOR SEDATION AFTER AORTIC SURGERY

Sixteen patients who had undergone abdominal aortic surgery were allocated randomly to receive either propofol (total dose 3.2 (SEM 0.3) mg kg−1 h−1) or flunitrazepam (total dose 15 (2) μg kg−1 h−1) for 16 h after operation. Metabolic effects of sedation were assessed using a Deltatrac metabolic mon...

Full description

Saved in:
Bibliographic Details
Published in:British Journal of Anaesthesia 1993-04, Vol.70 (4), p.451-453
Main Authors: MORITZ, F., PETIT, J., KAEFFER, N., OKSENHENDLER, G., PAPION, H., HECKETSWEILER, B., MOORE, N., WINCKLER, C.
Format: Article
Language:English
Subjects:
Anaesthetics intravenous: propofol
Anesthetics. Neuromuscular blocking agents
Aortic Aneurysm, Abdominal - surgery
benzo-diazepines: fluitrazepam
Biological and medical sciences
Blood Pressure - drug effects
Energy Metabolism - drug effects
Flunitrazepam - pharmacology
Humans
Hypnotics
Medical sciences
Metabolism: oxygen consumption
Neuropharmacology
Norepinephrine - blood
Oxygen Consumption - drug effects
Pharmacology. Drug treatments
Postoperative Care
Propofol - pharmacology
Recovery postoperative sedation
Time Factors
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Sixteen patients who had undergone abdominal aortic surgery were allocated randomly to receive either propofol (total dose 3.2 (SEM 0.3) mg kg−1 h−1) or flunitrazepam (total dose 15 (2) μg kg−1 h−1) for 16 h after operation. Metabolic effects of sedation were assessed using a Deltatrac metabolic monitor. Initiation of sedation induced a 25% decrease in Vo2 in both groups. The decrease was about 40% at 16 h. Vo2 increased within 30 min after discontinuation of propofol and stabilized at values considerably less than the immediate postoperative value. A similar but slower increase was noted with flunitrazepam. While the propofol loading dose reduced the Buffington index and should therefore be avoided, no cardiovascular side effects were noted with the maintenance infusion. Weaning from ventilatorl support was achieved within 15 (2) min and 264 (108) min after discontinuation of propofol and flunitrazepam, respectively. (Br. J. Anaesth. 1993; 70: 451–453)
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/70.4.451