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Prospective respiratory-triggered 64-slice CT pulmonary angiography for detection of pulmonary embolism—a feasibility study in a porcine model
The objective of this study is to investigate the feasibility of prospectively respiratory-triggered CT pulmonary angiography (CTPA) for detection of pulmonary embolism (PE) in a porcine model. A free-breathing respiratory-triggered multislice CTPA (120 kV, 140 mAs eff , 2.5-mm slice thickness) and...
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| Published in: | Emergency radiology 2010-11, Vol.17 (6), p.465-471 |
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| Main Authors: | , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c371t-46118190a0d69f55bad08079369e67ac41b37799eaad8fee459eda4f833d726e3 |
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| cites | cdi_FETCH-LOGICAL-c371t-46118190a0d69f55bad08079369e67ac41b37799eaad8fee459eda4f833d726e3 |
| container_end_page | 471 |
| container_issue | 6 |
| container_start_page | 465 |
| container_title | Emergency radiology |
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| creator | Henes, Frank Oliver G. Groth, Michael Regier, Marc Bley, Thorsten Nagel, Hans-Dieter Adam, Gerhard Begemann, Philipp G. C. |
| description | The objective of this study is to investigate the feasibility of prospectively respiratory-triggered CT pulmonary angiography (CTPA) for detection of pulmonary embolism (PE) in a porcine model. A free-breathing respiratory-triggered multislice CTPA (120 kV, 140 mAs
eff
, 2.5-mm slice thickness) and two CTPA in breath-hold technique (120 kV, 140 mAs
eff.
and 250mAs
eff
, 1-mm and 3-mm image reconstruction) were performed in six pigs with pulmonary embolism. Diagnostic accuracy was computed, and differences in detection rates between both techniques were assessed on a per-embolus basis with the Wilcoxon test. Thin-sliced 1-mm images, acquired with 250mAs
eff
, served as the standard of reference. Respiratory-triggered CTPA reached high diagnostic accuracy in detection of lobar and segmental PE equal to the results with the breath-hold technique (
p
> 0.05). For detection of subsegmental emboli, standard breath-hold techniques performed significantly better than respiratory-gated CTPA (sensitivity, 68.3% versus 24.4%;
p
|
| doi_str_mv | 10.1007/s10140-010-0887-6 |
| format | article |
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eff
, 2.5-mm slice thickness) and two CTPA in breath-hold technique (120 kV, 140 mAs
eff.
and 250mAs
eff
, 1-mm and 3-mm image reconstruction) were performed in six pigs with pulmonary embolism. Diagnostic accuracy was computed, and differences in detection rates between both techniques were assessed on a per-embolus basis with the Wilcoxon test. Thin-sliced 1-mm images, acquired with 250mAs
eff
, served as the standard of reference. Respiratory-triggered CTPA reached high diagnostic accuracy in detection of lobar and segmental PE equal to the results with the breath-hold technique (
p
> 0.05). For detection of subsegmental emboli, standard breath-hold techniques performed significantly better than respiratory-gated CTPA (sensitivity, 68.3% versus 24.4%;
p
< 0.05). Free-breathing respiratory-triggered CTPA is feasible for detection of lobar and segmental PE, with diagnostic accuracy equivalent to that of a standard CTPA in breath-hold. Although this technique is not recommended for assessment of emboli in the subsegmental vasculature, prospective respiratory-triggered CTPA may be of added value in patients who cannot hold their breath appropriately for CTPA scanning.</description><identifier>ISSN: 1070-3004</identifier><identifier>EISSN: 1438-1435</identifier><identifier>DOI: 10.1007/s10140-010-0887-6</identifier><identifier>PMID: 20607338</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Angiography - methods ; Animals ; Emergency Medicine ; Feasibility Studies ; Imaging ; Medicine ; Medicine & Public Health ; Original Article ; Predictive Value of Tests ; Prospective Studies ; Pulmonary Embolism - diagnostic imaging ; Radiographic Image Interpretation, Computer-Assisted ; Radiology ; Respiratory-Gated Imaging Techniques - methods ; Sensitivity and Specificity ; Statistics, Nonparametric ; Swine ; Tomography, X-Ray Computed - methods</subject><ispartof>Emergency radiology, 2010-11, Vol.17 (6), p.465-471</ispartof><rights>Am Soc Emergency Radiol 2010</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c371t-46118190a0d69f55bad08079369e67ac41b37799eaad8fee459eda4f833d726e3</citedby><cites>FETCH-LOGICAL-c371t-46118190a0d69f55bad08079369e67ac41b37799eaad8fee459eda4f833d726e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20607338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Henes, Frank Oliver G.</creatorcontrib><creatorcontrib>Groth, Michael</creatorcontrib><creatorcontrib>Regier, Marc</creatorcontrib><creatorcontrib>Bley, Thorsten</creatorcontrib><creatorcontrib>Nagel, Hans-Dieter</creatorcontrib><creatorcontrib>Adam, Gerhard</creatorcontrib><creatorcontrib>Begemann, Philipp G. C.</creatorcontrib><title>Prospective respiratory-triggered 64-slice CT pulmonary angiography for detection of pulmonary embolism—a feasibility study in a porcine model</title><title>Emergency radiology</title><addtitle>Emerg Radiol</addtitle><addtitle>Emerg Radiol</addtitle><description>The objective of this study is to investigate the feasibility of prospectively respiratory-triggered CT pulmonary angiography (CTPA) for detection of pulmonary embolism (PE) in a porcine model. A free-breathing respiratory-triggered multislice CTPA (120 kV, 140 mAs
eff
, 2.5-mm slice thickness) and two CTPA in breath-hold technique (120 kV, 140 mAs
eff.
and 250mAs
eff
, 1-mm and 3-mm image reconstruction) were performed in six pigs with pulmonary embolism. Diagnostic accuracy was computed, and differences in detection rates between both techniques were assessed on a per-embolus basis with the Wilcoxon test. Thin-sliced 1-mm images, acquired with 250mAs
eff
, served as the standard of reference. Respiratory-triggered CTPA reached high diagnostic accuracy in detection of lobar and segmental PE equal to the results with the breath-hold technique (
p
> 0.05). For detection of subsegmental emboli, standard breath-hold techniques performed significantly better than respiratory-gated CTPA (sensitivity, 68.3% versus 24.4%;
p
< 0.05). Free-breathing respiratory-triggered CTPA is feasible for detection of lobar and segmental PE, with diagnostic accuracy equivalent to that of a standard CTPA in breath-hold. Although this technique is not recommended for assessment of emboli in the subsegmental vasculature, prospective respiratory-triggered CTPA may be of added value in patients who cannot hold their breath appropriately for CTPA scanning.</description><subject>Angiography - methods</subject><subject>Animals</subject><subject>Emergency Medicine</subject><subject>Feasibility Studies</subject><subject>Imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Pulmonary Embolism - diagnostic imaging</subject><subject>Radiographic Image Interpretation, Computer-Assisted</subject><subject>Radiology</subject><subject>Respiratory-Gated Imaging Techniques - methods</subject><subject>Sensitivity and Specificity</subject><subject>Statistics, Nonparametric</subject><subject>Swine</subject><subject>Tomography, X-Ray Computed - methods</subject><issn>1070-3004</issn><issn>1438-1435</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp1kctu1TAQhi0EoqXtA7BBlliwCoxjx5clOuJSqRIsytpy4snBVRIHO0HKro_AgifkSeqjU1CF1IUvkr_5x5qPkJcM3jIA9S4zYAIqYGVprSr5hJwywXVVtuZpuYOCigOIE_Ii5xsAkEbq5-SkBgmKc31Kfn1NMc_YLeEn0oR5DsktMW3VksJ-jwk9laLKQ-iQ7q7pvA5jnFzaqJv2Ie6Tm79vtI-JelwOKXGisX-A4djGIeTxz-1vR3t0ObRhCMtG87L6jYaJOjrH1IUJ6Rg9DufkWe-GjBf35xn59vHD9e5zdfXl0-Xu_VXVccWWSkjGNDPgwEvTN03rPGhQhkuDUrlOsJYrZQw653WPKBqD3olec-5VLZGfkTfH3DnFHyvmxY4hdzgMbsK4ZqsaJWTNjSjk6__Im7imqXzOMlFrA1qZplDsSHVloDlhb-cUxjICy8AebNmjLVts2YMtK0vNq_vktR3R_6v4q6cA9RHI5WkqOh60fjT1DrKmovE</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Henes, Frank Oliver G.</creator><creator>Groth, Michael</creator><creator>Regier, Marc</creator><creator>Bley, Thorsten</creator><creator>Nagel, Hans-Dieter</creator><creator>Adam, Gerhard</creator><creator>Begemann, Philipp G. C.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Prospective respiratory-triggered 64-slice CT pulmonary angiography for detection of pulmonary embolism—a feasibility study in a porcine model</title><author>Henes, Frank Oliver G. ; Groth, Michael ; Regier, Marc ; Bley, Thorsten ; Nagel, Hans-Dieter ; Adam, Gerhard ; Begemann, Philipp G. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c371t-46118190a0d69f55bad08079369e67ac41b37799eaad8fee459eda4f833d726e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Angiography - methods</topic><topic>Animals</topic><topic>Emergency Medicine</topic><topic>Feasibility Studies</topic><topic>Imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Pulmonary Embolism - diagnostic imaging</topic><topic>Radiographic Image Interpretation, Computer-Assisted</topic><topic>Radiology</topic><topic>Respiratory-Gated Imaging Techniques - methods</topic><topic>Sensitivity and Specificity</topic><topic>Statistics, Nonparametric</topic><topic>Swine</topic><topic>Tomography, X-Ray Computed - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Henes, Frank Oliver G.</creatorcontrib><creatorcontrib>Groth, Michael</creatorcontrib><creatorcontrib>Regier, Marc</creatorcontrib><creatorcontrib>Bley, Thorsten</creatorcontrib><creatorcontrib>Nagel, Hans-Dieter</creatorcontrib><creatorcontrib>Adam, Gerhard</creatorcontrib><creatorcontrib>Begemann, Philipp G. C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Emergency radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Henes, Frank Oliver G.</au><au>Groth, Michael</au><au>Regier, Marc</au><au>Bley, Thorsten</au><au>Nagel, Hans-Dieter</au><au>Adam, Gerhard</au><au>Begemann, Philipp G. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective respiratory-triggered 64-slice CT pulmonary angiography for detection of pulmonary embolism—a feasibility study in a porcine model</atitle><jtitle>Emergency radiology</jtitle><stitle>Emerg Radiol</stitle><addtitle>Emerg Radiol</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>17</volume><issue>6</issue><spage>465</spage><epage>471</epage><pages>465-471</pages><issn>1070-3004</issn><eissn>1438-1435</eissn><abstract>The objective of this study is to investigate the feasibility of prospectively respiratory-triggered CT pulmonary angiography (CTPA) for detection of pulmonary embolism (PE) in a porcine model. A free-breathing respiratory-triggered multislice CTPA (120 kV, 140 mAs
eff
, 2.5-mm slice thickness) and two CTPA in breath-hold technique (120 kV, 140 mAs
eff.
and 250mAs
eff
, 1-mm and 3-mm image reconstruction) were performed in six pigs with pulmonary embolism. Diagnostic accuracy was computed, and differences in detection rates between both techniques were assessed on a per-embolus basis with the Wilcoxon test. Thin-sliced 1-mm images, acquired with 250mAs
eff
, served as the standard of reference. Respiratory-triggered CTPA reached high diagnostic accuracy in detection of lobar and segmental PE equal to the results with the breath-hold technique (
p
> 0.05). For detection of subsegmental emboli, standard breath-hold techniques performed significantly better than respiratory-gated CTPA (sensitivity, 68.3% versus 24.4%;
p
< 0.05). Free-breathing respiratory-triggered CTPA is feasible for detection of lobar and segmental PE, with diagnostic accuracy equivalent to that of a standard CTPA in breath-hold. Although this technique is not recommended for assessment of emboli in the subsegmental vasculature, prospective respiratory-triggered CTPA may be of added value in patients who cannot hold their breath appropriately for CTPA scanning.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>20607338</pmid><doi>10.1007/s10140-010-0887-6</doi><tpages>7</tpages></addata></record> |
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| ispartof | Emergency radiology, 2010-11, Vol.17 (6), p.465-471 |
| issn | 1070-3004 1438-1435 |
| language | eng |
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| source | Springer Nature |
| subjects | Angiography - methods Animals Emergency Medicine Feasibility Studies Imaging Medicine Medicine & Public Health Original Article Predictive Value of Tests Prospective Studies Pulmonary Embolism - diagnostic imaging Radiographic Image Interpretation, Computer-Assisted Radiology Respiratory-Gated Imaging Techniques - methods Sensitivity and Specificity Statistics, Nonparametric Swine Tomography, X-Ray Computed - methods |
| title | Prospective respiratory-triggered 64-slice CT pulmonary angiography for detection of pulmonary embolism—a feasibility study in a porcine model |
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