Triclosan resistance in methicillin-resistant Staphylococcus aureus (MRSA)

Two triclosan selected mutants showed four-fold and 16-fold increases in their minimum inhibitory concentrations (MICs) of triclosan (1 mg/L and 4 mg/L) compared with their parent strains. Four clinical isolates of MRSA were detected with the same triclosan susceptibility as the mutants. One mutant...

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Bibliographic Details
Published in:The Journal of hospital infection 2003-10, Vol.55 (2), p.141-144
Main Authors: Brenwald, N.P, Fraise, A.P
Format: Article
Language:English
Subjects:
Anti-Infective Agents, Local - pharmacology
Bacterial diseases
Biological and medical sciences
Drug Resistance, Microbial - genetics
Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)
FabI protein
Human bacterial diseases
Humans
Infectious diseases
Medical sciences
Methicillin Resistance - drug effects
Methicillin Resistance - genetics
Microbial Sensitivity Tests
MRSA
Oxidoreductases - genetics
Staphylococcal infections, streptococcal infections, pneumococcal infections
Staphylococcus aureus
Staphylococcus aureus - drug effects
Staphylococcus aureus - genetics
Triclosan
Triclosan - pharmacology
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Summary:Two triclosan selected mutants showed four-fold and 16-fold increases in their minimum inhibitory concentrations (MICs) of triclosan (1 mg/L and 4 mg/L) compared with their parent strains. Four clinical isolates of MRSA were detected with the same triclosan susceptibility as the mutants. One mutant had a predicted change in the gene product on FabI (Thr 147→His), whilst only one clinical isolate had predicted FabI amino-acid changes (Ala 198→Gly, and Leu 208→Phe). The lack of fabI mutations in one mutant and three of the clinical isolates showing reduced triclosan susceptibility suggest that genetic loci other than fabI may be involved in triclosan resistance.
ISSN:0195-6701
1532-2939
DOI:10.1016/S0195-6701(03)00222-6