Neuronal Ceroid-Lipofuscinosis in a Labrador Retriever

An 8-year-old Labrador Retriever with an 11-month history of progressive partial seizures and necropsy examination findings characteristic of the lamellar form of canine neuronal ceroid-lipofuscinosis (NCL) is presented. The clinical, light microscopic, and ultrastructural features of this case most...

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Bibliographic Details
Published in:Journal of veterinary diagnostic investigation 2003-09, Vol.15 (5), p.457-460
Main Authors: Rossmeisl, John H. Jr, Duncan, Robert, Fox, Jonathan, Herring, Erin S, Inzana, Karen D
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Dog Diseases - pathology
Dogs
Fundamental and applied biological sciences. Psychology
humans
Labrador Retriever
Male
Microbiology
Motor Neurons - pathology
Motor Neurons - ultrastructure
necropsy
Neuronal Ceroid-Lipofuscinoses - pathology
Neuronal Ceroid-Lipofuscinoses - veterinary
Periaqueductal Gray - pathology
seizures
Spinal Cord - pathology
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Summary:An 8-year-old Labrador Retriever with an 11-month history of progressive partial seizures and necropsy examination findings characteristic of the lamellar form of canine neuronal ceroid-lipofuscinosis (NCL) is presented. The clinical, light microscopic, and ultrastructural features of this case most closely resemble human adult-onset NCL (Kufs disease). This is the first report of NCL occurring in the Labrador Retriever breed.
ISSN:1040-6387
1943-4936
DOI:10.1177/104063870301500509