The use of static pressures of heavy gases within a quadrupole ion trap

The performance of quadrupole ion traps using argon or air as the buffer gas was evaluated and compared to the standard helium only operation. In all cases a pure buffer gas, not mixtures of gases, was investigated. Experiments were performed on a Bruker Esquire ion trap, a Finnigan LCQ, and a Finni...

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Bibliographic Details
Published in:Journal of the American Society for Mass Spectrometry 2003-10, Vol.14 (10), p.1099-1109
Main Authors: Danell, Ryan M, Danell, Allison S, Glish, Gary L, Vachet, Richard W
Format: Article
Language:English
Subjects:
Analytical chemistry
Argon - chemistry
Buffers
Chemical Phenomena
Chemistry
Chemistry, Physical
Deactivation
Ejection
Enkephalin, Leucine - analysis
Enkephalin, Leucine - chemistry
Exact sciences and technology
Gases - chemistry
Helium
Helium - chemistry
Ion traps (instrumentation)
Ions
Mass spectrometry
Mass Spectrometry - methods
Pressure
Quadrupoles
Sensitivity and Specificity
Spectrometric and optical methods
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Summary:The performance of quadrupole ion traps using argon or air as the buffer gas was evaluated and compared to the standard helium only operation. In all cases a pure buffer gas, not mixtures of gases, was investigated. Experiments were performed on a Bruker Esquire ion trap, a Finnigan LCQ, and a Finnigan ITMS for comparison. The heavier gases were found to have some advantages, particularly in the areas of sensitivity and collision-induced dissociation efficiency; however, there is a significant resolution loss due to dissociation and/or scattering of ions. Additionally, the heavier gases were found to affect ion activation and deactivation during MS/MS, influencing the product ion intensities observed. Finally, the specific quadrupole ion trap design and the ion ejection parameters were found to be crucial in the quality of the spectra obtained in the presence of heavy gases. Operation with static pressures of heavy gases can be beneficial under certain design and operating conditions of the quadrupole ion trap.
ISSN:1044-0305
1879-1123
DOI:10.1016/S1044-0305(03)00404-5