Stem Cells in the News: CNN and APC Make Headlines

Stem cell self-renewal depends on their ability to divide asymmetrically, with one daughter retaining stem cell identity. This often involves precise orchestration of mitotic spindle orientation, but the machinery used to ensure this outcome is understood in only a handful of examples. In a recent i...

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Bibliographic Details
Published in:Developmental Cell 2003-10, Vol.5 (4), p.532-534
Main Authors: McCartney, Brooke M, Peifer, Mark
Format: Article
Language:English
Subjects:
Animals
Cell Division
Centrosome - physiology
Cytoskeletal Proteins - physiology
Drosophila
Drosophila Proteins - physiology
Homeodomain Proteins - physiology
Male
Models, Biological
Sequence Homology
Spindle Apparatus - genetics
Spindle Apparatus - physiology
Stem Cells - physiology
Tumor Suppressor Proteins - metabolism
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Summary:Stem cell self-renewal depends on their ability to divide asymmetrically, with one daughter retaining stem cell identity. This often involves precise orchestration of mitotic spindle orientation, but the machinery used to ensure this outcome is understood in only a handful of examples. In a recent issue of Science, Yamashita et al. provide new insights into the factors that control this process in the male germline of Drosophila, identifying roles for the centrosomal protein Centrosomin and tumor suppressor homologs of the APC family.
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(03)00300-9