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Stem Cells in the News: CNN and APC Make Headlines

Stem cell self-renewal depends on their ability to divide asymmetrically, with one daughter retaining stem cell identity. This often involves precise orchestration of mitotic spindle orientation, but the machinery used to ensure this outcome is understood in only a handful of examples. In a recent i...

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Published in:	Developmental Cell 2003-10, Vol.5 (4), p.532-534
Main Authors:	McCartney, Brooke M, Peifer, Mark
Format:	Article
Language:	English
Subjects:	Animals Cell Division Centrosome - physiology Cytoskeletal Proteins - physiology Drosophila Drosophila Proteins - physiology Homeodomain Proteins - physiology Male Models, Biological Sequence Homology Spindle Apparatus - genetics Spindle Apparatus - physiology Stem Cells - physiology Tumor Suppressor Proteins - metabolism
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container_title	Developmental Cell
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creator	McCartney, Brooke M Peifer, Mark
description	Stem cell self-renewal depends on their ability to divide asymmetrically, with one daughter retaining stem cell identity. This often involves precise orchestration of mitotic spindle orientation, but the machinery used to ensure this outcome is understood in only a handful of examples. In a recent issue of Science, Yamashita et al. provide new insights into the factors that control this process in the male germline of Drosophila, identifying roles for the centrosomal protein Centrosomin and tumor suppressor homologs of the APC family.
doi_str_mv	10.1016/S1534-5807(03)00300-9
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subjects	Animals Cell Division Centrosome - physiology Cytoskeletal Proteins - physiology Drosophila Drosophila Proteins - physiology Homeodomain Proteins - physiology Male Models, Biological Sequence Homology Spindle Apparatus - genetics Spindle Apparatus - physiology Stem Cells - physiology Tumor Suppressor Proteins - metabolism
title	Stem Cells in the News: CNN and APC Make Headlines
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