Localisation of the gene for multiple endocrine neoplasia type 2A to a 480 kb region in chromosome band 10q11.2

A YAC contig has been constructed spanning 1.1 Mb of human chromosome band 10q11.2 which encompasses three markers (D10S141, RET, D10S94) closely linked to the gene for MEN 2A. This physical linkage group is ordered cen-D10S141-RET-D10S94-qter, and must include MEN2A, which lies in a 480 kb region b...

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Bibliographic Details
Published in:Human molecular genetics 1993-03, Vol.2 (3), p.247-252
Main Authors: Mole, Sara E., Mulligan, Lois M., Healey, Catherine S., Ponder, Bruce A.J., Tunnacliffe, Alan
Format: Article
Language:English
Subjects:
Base Sequence
Biological and medical sciences
chromosome 10
Chromosome Mapping
Chromosomes, Fungal
Chromosomes, Human, Pair 10
DNA - genetics
Endocrinopathies
Gene Library
genes
Genetic Linkage
Genetic Markers
Genome, Human
Humans
localization
Malignant tumors
man
Medical sciences
Molecular Sequence Data
multiple endocrine neoplasia
Multiple Endocrine Neoplasia - genetics
Oncogenes
Restriction Mapping
Thyroid. Thyroid axis (diseases)
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Summary:A YAC contig has been constructed spanning 1.1 Mb of human chromosome band 10q11.2 which encompasses three markers (D10S141, RET, D10S94) closely linked to the gene for MEN 2A. This physical linkage group is ordered cen-D10S141-RET-D10S94-qter, and must include MEN2A, which lies in a 480 kb region between flanking markers D10S141 and D10S94.
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/2.3.247