The control of nitrilotriacetic acid in edetic acid and its salts by liquid chromatography

Two liquid chromatographic methods have been developed and validated for the determination of nitrilotriacetic acid (NTA) in edetic acid (EDTA) and its salts. In one method NTA and EDTA are separated on a polymer column without pretreatment, and are detected amperometrically using a glassy-carbon el...

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Bibliographic Details
Published in:Journal of pharmaceutical and biomedical analysis 2003-10, Vol.33 (3), p.435-440
Main Authors: Crosbie, G.A, Lodi, A, McB Miller, J.H, Skellern, G.G
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Chromatography, Liquid - methods
Complexation
Edetic Acid - analysis
EDTA
Fundamental and applied biological sciences. Psychology
General pharmacology
Medical sciences
Nitrilotriacetic acid
Nitrilotriacetic Acid - analysis
Pharmacology. Drug treatments
Porous graphite carbon amperometry
Reversed-phase chromatography
Salts - analysis
Technology, Pharmaceutical - methods
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Summary:Two liquid chromatographic methods have been developed and validated for the determination of nitrilotriacetic acid (NTA) in edetic acid (EDTA) and its salts. In one method NTA and EDTA are separated on a polymer column without pretreatment, and are detected amperometrically using a glassy-carbon electrode. In the other method NTA and EDTA are complexed with ferric ions and the complexes separated on a porous graphite carbon stationary phase with ultraviolet detection at 215 nm. Both methods were sufficiently selected and sensitive to allow the control of NTA (0.1% m/m) in sample of EDTA and its salts.
ISSN:0731-7085
1873-264X
DOI:10.1016/S0731-7085(03)00291-7