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Plasma levels of cortisol and corticosteroid-binding globulin (CBG) and hepatic CBG mRNA expression in pre- and postnatal pigs
The relationships among hepatic corticosteroid-binding globulin (CBG) mRNA expression and plasma concentrations of cortisol and CBG was evaluated in fetal pigs ( n=7–14 per age) on days 50, 70, 80, 90, and 104 of gestation and postnatal pigs ( n=8 per age) on days 1, 3, 10, 20, 30, and 40 following...
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| Published in: | Domestic animal endocrinology 2003-10, Vol.25 (3), p.263-273 |
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| cites | cdi_FETCH-LOGICAL-c451t-8ee379c229e8cdefefbf17a21e747e2a0d7f72c51babf79334826f6fd8b717a33 |
| container_end_page | 273 |
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| container_title | Domestic animal endocrinology |
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| creator | Heo, Jeonghoon Kattesh, Henry G Roberts, Mary P Schneider, John F |
| description | The relationships among hepatic corticosteroid-binding globulin (CBG) mRNA expression and plasma concentrations of cortisol and CBG was evaluated in fetal pigs (
n=7–14 per age) on days 50, 70, 80, 90, and 104 of gestation and postnatal pigs (
n=8 per age) on days 1, 3, 10, 20, 30, and 40 following birth. In fetal pigs, hepatic CBG mRNA expression was highest (
P |
| doi_str_mv | 10.1016/S0739-7240(03)00055-9 |
| format | article |
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n=7–14 per age) on days 50, 70, 80, 90, and 104 of gestation and postnatal pigs (
n=8 per age) on days 1, 3, 10, 20, 30, and 40 following birth. In fetal pigs, hepatic CBG mRNA expression was highest (
P<0.01) on day 50 as compared to days 90 and 104, exhibiting an overall negative relationship (
r=−0.63;
P<0.01) with estimated gestation age. Plasma porcine CBG (pCBG) concentration was correlated (
r=0.34;
P<0.05) with hepatic CBG mRNA level. Plasma cortisol concentrations were not different over this same period. In postnatal pigs, hepatic CBG mRNA expression increased (
P<0.01) from days 3 to 40. The pCBG concentration increased (
P<0.01) from days 1 (6.1±3.4
μg/ml) to 10 (15.1±3.7
μg/ml), while plasma cortisol concentration remained constant. An understanding of the relation between hepatic CBG mRNA and circulating pCBG concentrations may provide insight into the mechanisms determining the bioavailability of cortisol necessary in prenatal development and the conservation of cortisol during postnatal development in the pig.</description><identifier>ISSN: 0739-7240</identifier><identifier>EISSN: 1879-0054</identifier><identifier>DOI: 10.1016/S0739-7240(03)00055-9</identifier><identifier>PMID: 14550510</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aging - blood ; Animals ; bioavailability ; CBG ; CBG mRNA ; Cortisol ; Female ; Fetal Blood - metabolism ; gene expression ; Gene Expression Regulation, Developmental ; Hydrocortisone - blood ; Liver - embryology ; Liver - metabolism ; messenger RNA ; postnatal development ; Pre- and postnatal pigs ; Pregnancy ; prenatal development ; Radioimmunoassay - veterinary ; Random Allocation ; RNA, Messenger - analysis ; swine ; Swine - blood ; Swine - embryology ; Transcortin - genetics ; Transcortin - metabolism</subject><ispartof>Domestic animal endocrinology, 2003-10, Vol.25 (3), p.263-273</ispartof><rights>2003 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-8ee379c229e8cdefefbf17a21e747e2a0d7f72c51babf79334826f6fd8b717a33</citedby><cites>FETCH-LOGICAL-c451t-8ee379c229e8cdefefbf17a21e747e2a0d7f72c51babf79334826f6fd8b717a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14550510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heo, Jeonghoon</creatorcontrib><creatorcontrib>Kattesh, Henry G</creatorcontrib><creatorcontrib>Roberts, Mary P</creatorcontrib><creatorcontrib>Schneider, John F</creatorcontrib><title>Plasma levels of cortisol and corticosteroid-binding globulin (CBG) and hepatic CBG mRNA expression in pre- and postnatal pigs</title><title>Domestic animal endocrinology</title><addtitle>Domest Anim Endocrinol</addtitle><description>The relationships among hepatic corticosteroid-binding globulin (CBG) mRNA expression and plasma concentrations of cortisol and CBG was evaluated in fetal pigs (
n=7–14 per age) on days 50, 70, 80, 90, and 104 of gestation and postnatal pigs (
n=8 per age) on days 1, 3, 10, 20, 30, and 40 following birth. In fetal pigs, hepatic CBG mRNA expression was highest (
P<0.01) on day 50 as compared to days 90 and 104, exhibiting an overall negative relationship (
r=−0.63;
P<0.01) with estimated gestation age. Plasma porcine CBG (pCBG) concentration was correlated (
r=0.34;
P<0.05) with hepatic CBG mRNA level. Plasma cortisol concentrations were not different over this same period. In postnatal pigs, hepatic CBG mRNA expression increased (
P<0.01) from days 3 to 40. The pCBG concentration increased (
P<0.01) from days 1 (6.1±3.4
μg/ml) to 10 (15.1±3.7
μg/ml), while plasma cortisol concentration remained constant. An understanding of the relation between hepatic CBG mRNA and circulating pCBG concentrations may provide insight into the mechanisms determining the bioavailability of cortisol necessary in prenatal development and the conservation of cortisol during postnatal development in the pig.</description><subject>Aging - blood</subject><subject>Animals</subject><subject>bioavailability</subject><subject>CBG</subject><subject>CBG mRNA</subject><subject>Cortisol</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Hydrocortisone - blood</subject><subject>Liver - embryology</subject><subject>Liver - metabolism</subject><subject>messenger RNA</subject><subject>postnatal development</subject><subject>Pre- and postnatal pigs</subject><subject>Pregnancy</subject><subject>prenatal development</subject><subject>Radioimmunoassay - veterinary</subject><subject>Random Allocation</subject><subject>RNA, Messenger - analysis</subject><subject>swine</subject><subject>Swine - blood</subject><subject>Swine - embryology</subject><subject>Transcortin - genetics</subject><subject>Transcortin - metabolism</subject><issn>0739-7240</issn><issn>1879-0054</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqF0c9vFCEUB3BibOxa_RNUTk17GOXnMnMy7UZrk0aNtWfCwGPFMMMIs41e_NulOxs9eoJHPu9BviD0gpLXlND1m1uieNcoJsgZ4eeEECmb7hFa0VZ1Ta3EY7T6S47R01K-V6Rq7xN0TIWURFKyQr8_R1MGgyPcQyw4eWxTnkNJEZvRLYVNZYacgmv6MLowbvE2pn4Xw4jPNpdX53v5DSZTKa4HePjy8QLDzylDKSGNuMK6b_ZuqsNGM5uIp7Atz9CRN7HA88N6gu7ev_u6-dDcfLq63lzcNFZIOjctAFedZayD1jrw4HtPlWEUlFDADHHKK2Yl7U3vVce5aNnar71re1Ud5yfodJk75fRjB2XWQygWYjQjpF3RSiq5FpRVKBdocyolg9dTDoPJvzQl-iF4vQ9eP6SqCdf74HVX-14eLtj1A7h_XYekK3i1AG-SNtscir67ZYQKQqjkkosq3i6ifgTcB8i62ACjBRcy2Fm7FP7ziD_GqJyy</recordid><startdate>20031001</startdate><enddate>20031001</enddate><creator>Heo, Jeonghoon</creator><creator>Kattesh, Henry G</creator><creator>Roberts, Mary P</creator><creator>Schneider, John F</creator><general>Elsevier Inc</general><general>Elsevier Science Pub. Co</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20031001</creationdate><title>Plasma levels of cortisol and corticosteroid-binding globulin (CBG) and hepatic CBG mRNA expression in pre- and postnatal pigs</title><author>Heo, Jeonghoon ; Kattesh, Henry G ; Roberts, Mary P ; Schneider, John F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-8ee379c229e8cdefefbf17a21e747e2a0d7f72c51babf79334826f6fd8b717a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aging - blood</topic><topic>Animals</topic><topic>bioavailability</topic><topic>CBG</topic><topic>CBG mRNA</topic><topic>Cortisol</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Hydrocortisone - blood</topic><topic>Liver - embryology</topic><topic>Liver - metabolism</topic><topic>messenger RNA</topic><topic>postnatal development</topic><topic>Pre- and postnatal pigs</topic><topic>Pregnancy</topic><topic>prenatal development</topic><topic>Radioimmunoassay - veterinary</topic><topic>Random Allocation</topic><topic>RNA, Messenger - analysis</topic><topic>swine</topic><topic>Swine - blood</topic><topic>Swine - embryology</topic><topic>Transcortin - genetics</topic><topic>Transcortin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heo, Jeonghoon</creatorcontrib><creatorcontrib>Kattesh, Henry G</creatorcontrib><creatorcontrib>Roberts, Mary P</creatorcontrib><creatorcontrib>Schneider, John F</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Domestic animal endocrinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heo, Jeonghoon</au><au>Kattesh, Henry G</au><au>Roberts, Mary P</au><au>Schneider, John F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma levels of cortisol and corticosteroid-binding globulin (CBG) and hepatic CBG mRNA expression in pre- and postnatal pigs</atitle><jtitle>Domestic animal endocrinology</jtitle><addtitle>Domest Anim Endocrinol</addtitle><date>2003-10-01</date><risdate>2003</risdate><volume>25</volume><issue>3</issue><spage>263</spage><epage>273</epage><pages>263-273</pages><issn>0739-7240</issn><eissn>1879-0054</eissn><abstract>The relationships among hepatic corticosteroid-binding globulin (CBG) mRNA expression and plasma concentrations of cortisol and CBG was evaluated in fetal pigs (
n=7–14 per age) on days 50, 70, 80, 90, and 104 of gestation and postnatal pigs (
n=8 per age) on days 1, 3, 10, 20, 30, and 40 following birth. In fetal pigs, hepatic CBG mRNA expression was highest (
P<0.01) on day 50 as compared to days 90 and 104, exhibiting an overall negative relationship (
r=−0.63;
P<0.01) with estimated gestation age. Plasma porcine CBG (pCBG) concentration was correlated (
r=0.34;
P<0.05) with hepatic CBG mRNA level. Plasma cortisol concentrations were not different over this same period. In postnatal pigs, hepatic CBG mRNA expression increased (
P<0.01) from days 3 to 40. The pCBG concentration increased (
P<0.01) from days 1 (6.1±3.4
μg/ml) to 10 (15.1±3.7
μg/ml), while plasma cortisol concentration remained constant. An understanding of the relation between hepatic CBG mRNA and circulating pCBG concentrations may provide insight into the mechanisms determining the bioavailability of cortisol necessary in prenatal development and the conservation of cortisol during postnatal development in the pig.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>14550510</pmid><doi>10.1016/S0739-7240(03)00055-9</doi><tpages>11</tpages></addata></record> |
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| ispartof | Domestic animal endocrinology, 2003-10, Vol.25 (3), p.263-273 |
| issn | 0739-7240 1879-0054 |
| language | eng |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Aging - blood Animals bioavailability CBG CBG mRNA Cortisol Female Fetal Blood - metabolism gene expression Gene Expression Regulation, Developmental Hydrocortisone - blood Liver - embryology Liver - metabolism messenger RNA postnatal development Pre- and postnatal pigs Pregnancy prenatal development Radioimmunoassay - veterinary Random Allocation RNA, Messenger - analysis swine Swine - blood Swine - embryology Transcortin - genetics Transcortin - metabolism |
| title | Plasma levels of cortisol and corticosteroid-binding globulin (CBG) and hepatic CBG mRNA expression in pre- and postnatal pigs |
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