Neonatal enucleation reduces the proportion of callosal boutons forming multiple synaptic contacts in rat striate cortex

Although bilateral enucleation at birth produces marked abnormalities in the overall distribution and topography of interhemispheric callosal connections in rat visual cortex, it is not known whether it also alters the morphology of callosal synapses. Here we report on the effect of neonatal enuclea...

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Bibliographic Details
Published in:Neuroscience letters 2003-11, Vol.351 (1), p.17-20
Main Authors: Sorensen, Staci A, Jones, Theresa A, Olavarria, Jaime F
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Corpus callosum
Corpus Callosum - physiology
Corpus Callosum - ultrastructure
Deprivation
Eye and associated structures. Visual pathways and centers. Vision
Eye Enucleation
Fundamental and applied biological sciences. Psychology
Multiple synaptic boutons
Neuronal Plasticity - physiology
Plasticity
Rats
Rats, Long-Evans
Synapses - physiology
Synaptogenesis
Vertebrates: nervous system and sense organs
Visual cortex
Visual Cortex - physiology
Visual Cortex - ultrastructure
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Summary:Although bilateral enucleation at birth produces marked abnormalities in the overall distribution and topography of interhemispheric callosal connections in rat visual cortex, it is not known whether it also alters the morphology of callosal synapses. Here we report on the effect of neonatal enucleation on the proportion of callosal boutons making multiple postsynaptic contacts. Synapses were analyzed in adult rats after injections of the anterograde tracer biotinylated dextran amine into the opposite striate cortex. Results show that neonatal enucleation produces a significant reduction in the proportion of callosal boutons making multiple postsynaptic contacts.
ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(03)00938-8