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Human Immunodeficiency Virus Type 1 RNA in Breast-Milk Components
We conducted the present study to determine which of the 4 components of breast milk (whole milk, skim milk, lipid layer, and breast-milk cells) had the highest sensitivity and concentration of human immunodeficiency virus (HIV) type 1 RNA burden and to determine biological correlates to these facto...
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| Published in: | The Journal of infectious diseases 2003-10, Vol.188 (8), p.1209-1212 |
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| Main Authors: | , , , , , , , , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c449t-1e62b9555b01bf3d0692903cec6f6511ac8e71f2acda3e2f39073d298a08d0d03 |
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| container_end_page | 1212 |
| container_issue | 8 |
| container_start_page | 1209 |
| container_title | The Journal of infectious diseases |
| container_volume | 188 |
| creator | Hoffman, Irving F. Martinson, Francis E. A. Stewart, Paul W. Chilongozi, David A. Leu, Szu-Yun Kazembe, Peter N. Banda, Topia Dzinyemba, Willard Joshi, Priya Cohen, Myron S. Fiscus, Susan A. |
| description | We conducted the present study to determine which of the 4 components of breast milk (whole milk, skim milk, lipid layer, and breast-milk cells) had the highest sensitivity and concentration of human immunodeficiency virus (HIV) type 1 RNA burden and to determine biological correlates to these factors. The probability of detection of HIV (sensitivity) and the concentration of HIV-1 RNA were both associated with the choice of milk component, CD4+ cell count, concentration of blood serum HIV-1 RNA, and the presence of breast inflammation. Whole milk demonstrated higher sensitivity and mean concentration than any other single component. Sensitivity was enhanced by analyzing all 4 components of breast milk |
| doi_str_mv | 10.1086/378414 |
| format | article |
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A. ; Stewart, Paul W. ; Chilongozi, David A. ; Leu, Szu-Yun ; Kazembe, Peter N. ; Banda, Topia ; Dzinyemba, Willard ; Joshi, Priya ; Cohen, Myron S. ; Fiscus, Susan A.</creator><creatorcontrib>Hoffman, Irving F. ; Martinson, Francis E. A. ; Stewart, Paul W. ; Chilongozi, David A. ; Leu, Szu-Yun ; Kazembe, Peter N. ; Banda, Topia ; Dzinyemba, Willard ; Joshi, Priya ; Cohen, Myron S. ; Fiscus, Susan A.</creatorcontrib><description>We conducted the present study to determine which of the 4 components of breast milk (whole milk, skim milk, lipid layer, and breast-milk cells) had the highest sensitivity and concentration of human immunodeficiency virus (HIV) type 1 RNA burden and to determine biological correlates to these factors. The probability of detection of HIV (sensitivity) and the concentration of HIV-1 RNA were both associated with the choice of milk component, CD4+ cell count, concentration of blood serum HIV-1 RNA, and the presence of breast inflammation. Whole milk demonstrated higher sensitivity and mean concentration than any other single component. Sensitivity was enhanced by analyzing all 4 components of breast milk</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1086/378414</identifier><identifier>PMID: 14551892</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Biological and medical sciences ; Blood ; Blood cells ; Breast milk ; Breasts ; Female ; Fundamental and applied biological sciences. Psychology ; HIV ; HIV 1 ; HIV Infections - transmission ; HIV Infections - virology ; HIV-1 - genetics ; HIV-1 - isolation & purification ; HIV-1 - physiology ; HIV/AIDS ; Human viral diseases ; Humans ; Infectious Disease Transmission, Vertical - prevention & control ; Infectious diseases ; Inflammation ; Lactation ; Mastitis - virology ; Medical sciences ; Microbiology ; Milk, Human - chemistry ; Milk, Human - cytology ; Milk, Human - virology ; Miscellaneous ; Pilot Projects ; RNA ; RNA, Viral - analysis ; Sensitivity and Specificity ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; Virology ; Viruses ; Women</subject><ispartof>The Journal of infectious diseases, 2003-10, Vol.188 (8), p.1209-1212</ispartof><rights>Copyright 2003 Infectious Diseases Society of America</rights><rights>2003 by the Infectious Diseases Society of America 2003</rights><rights>2004 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Oct 15 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c449t-1e62b9555b01bf3d0692903cec6f6511ac8e71f2acda3e2f39073d298a08d0d03</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30075733$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30075733$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,58238,58471</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15227916$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14551892$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoffman, Irving F.</creatorcontrib><creatorcontrib>Martinson, Francis E. A.</creatorcontrib><creatorcontrib>Stewart, Paul W.</creatorcontrib><creatorcontrib>Chilongozi, David A.</creatorcontrib><creatorcontrib>Leu, Szu-Yun</creatorcontrib><creatorcontrib>Kazembe, Peter N.</creatorcontrib><creatorcontrib>Banda, Topia</creatorcontrib><creatorcontrib>Dzinyemba, Willard</creatorcontrib><creatorcontrib>Joshi, Priya</creatorcontrib><creatorcontrib>Cohen, Myron S.</creatorcontrib><creatorcontrib>Fiscus, Susan A.</creatorcontrib><title>Human Immunodeficiency Virus Type 1 RNA in Breast-Milk Components</title><title>The Journal of infectious diseases</title><addtitle>The Journal of Infectious Diseases</addtitle><addtitle>The Journal of Infectious Diseases</addtitle><description>We conducted the present study to determine which of the 4 components of breast milk (whole milk, skim milk, lipid layer, and breast-milk cells) had the highest sensitivity and concentration of human immunodeficiency virus (HIV) type 1 RNA burden and to determine biological correlates to these factors. The probability of detection of HIV (sensitivity) and the concentration of HIV-1 RNA were both associated with the choice of milk component, CD4+ cell count, concentration of blood serum HIV-1 RNA, and the presence of breast inflammation. Whole milk demonstrated higher sensitivity and mean concentration than any other single component. Sensitivity was enhanced by analyzing all 4 components of breast milk</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood</subject><subject>Blood cells</subject><subject>Breast milk</subject><subject>Breasts</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>HIV</subject><subject>HIV 1</subject><subject>HIV Infections - transmission</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - isolation & purification</subject><subject>HIV-1 - physiology</subject><subject>HIV/AIDS</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious Disease Transmission, Vertical - prevention & control</subject><subject>Infectious diseases</subject><subject>Inflammation</subject><subject>Lactation</subject><subject>Mastitis - virology</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Milk, Human - chemistry</subject><subject>Milk, Human - cytology</subject><subject>Milk, Human - virology</subject><subject>Miscellaneous</subject><subject>Pilot Projects</subject><subject>RNA</subject><subject>RNA, Viral - analysis</subject><subject>Sensitivity and Specificity</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>Virology</subject><subject>Viruses</subject><subject>Women</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><recordid>eNqF0FFrFDEQB_AgFntW_QbKKujbaibZJJvH86pe4awgVcSXkMtmIdfdZJvsgvftm7JHDwrFvAQyP2Yyf4ReAf4IuOafqKgrqJ6gBTAqSs6BPkULjAkpoZbyFD1PaYcxrigXz9ApVIzld7JAy_XUa19c9P3kQ2NbZ5z1Zl_8dnFKxdV-sAUUPy-XhfPF52h1GsvvrrsuVqEfgrd-TC_QSau7ZF8e7jP06-uXq9W63Pz4drFabkpTVXIswXKylYyxLYZtSxvMJZGYGmt4yxmANrUV0BJtGk0taanEgjZE1hrXDW4wPUMf5r5DDDeTTaPqXTK267S3YUpKMMHqvN9_IdT5cAoZvnsAd2GKPi-hCMnzpYDq2M3EkFK0rRqi63XcK8DqLno1R5_hm0O3advb5sgOWWfw_gB0Mrpro_bGpaNjhAgJd_9_O7swDY8Pez2bXRpDvFcU4xwDpbleznWXRvvvvq7jteKCCqbWf_6q1XlFzi9hrTb0Fqeqqgs</recordid><startdate>20031015</startdate><enddate>20031015</enddate><creator>Hoffman, Irving F.</creator><creator>Martinson, Francis E. 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A. ; Stewart, Paul W. ; Chilongozi, David A. ; Leu, Szu-Yun ; Kazembe, Peter N. ; Banda, Topia ; Dzinyemba, Willard ; Joshi, Priya ; Cohen, Myron S. ; Fiscus, Susan A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c449t-1e62b9555b01bf3d0692903cec6f6511ac8e71f2acda3e2f39073d298a08d0d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood</topic><topic>Blood cells</topic><topic>Breast milk</topic><topic>Breasts</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>HIV</topic><topic>HIV 1</topic><topic>HIV Infections - transmission</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - isolation & purification</topic><topic>HIV-1 - physiology</topic><topic>HIV/AIDS</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious Disease Transmission, Vertical - prevention & control</topic><topic>Infectious diseases</topic><topic>Inflammation</topic><topic>Lactation</topic><topic>Mastitis - virology</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Milk, Human - chemistry</topic><topic>Milk, Human - cytology</topic><topic>Milk, Human - virology</topic><topic>Miscellaneous</topic><topic>Pilot Projects</topic><topic>RNA</topic><topic>RNA, Viral - analysis</topic><topic>Sensitivity and Specificity</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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A.</au><au>Stewart, Paul W.</au><au>Chilongozi, David A.</au><au>Leu, Szu-Yun</au><au>Kazembe, Peter N.</au><au>Banda, Topia</au><au>Dzinyemba, Willard</au><au>Joshi, Priya</au><au>Cohen, Myron S.</au><au>Fiscus, Susan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human Immunodeficiency Virus Type 1 RNA in Breast-Milk Components</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>The Journal of Infectious Diseases</stitle><addtitle>The Journal of Infectious Diseases</addtitle><date>2003-10-15</date><risdate>2003</risdate><volume>188</volume><issue>8</issue><spage>1209</spage><epage>1212</epage><pages>1209-1212</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>We conducted the present study to determine which of the 4 components of breast milk (whole milk, skim milk, lipid layer, and breast-milk cells) had the highest sensitivity and concentration of human immunodeficiency virus (HIV) type 1 RNA burden and to determine biological correlates to these factors. The probability of detection of HIV (sensitivity) and the concentration of HIV-1 RNA were both associated with the choice of milk component, CD4+ cell count, concentration of blood serum HIV-1 RNA, and the presence of breast inflammation. Whole milk demonstrated higher sensitivity and mean concentration than any other single component. Sensitivity was enhanced by analyzing all 4 components of breast milk</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>14551892</pmid><doi>10.1086/378414</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Journal of infectious diseases, 2003-10, Vol.188 (8), p.1209-1212 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | JSTOR Archival Journals and Primary Sources Collection; Oxford Journals Online |
| subjects | Adult Biological and medical sciences Blood Blood cells Breast milk Breasts Female Fundamental and applied biological sciences. Psychology HIV HIV 1 HIV Infections - transmission HIV Infections - virology HIV-1 - genetics HIV-1 - isolation & purification HIV-1 - physiology HIV/AIDS Human viral diseases Humans Infectious Disease Transmission, Vertical - prevention & control Infectious diseases Inflammation Lactation Mastitis - virology Medical sciences Microbiology Milk, Human - chemistry Milk, Human - cytology Milk, Human - virology Miscellaneous Pilot Projects RNA RNA, Viral - analysis Sensitivity and Specificity Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Virology Viruses Women |
| title | Human Immunodeficiency Virus Type 1 RNA in Breast-Milk Components |
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