Anthrax Toxin Induces Hemolysis: An Indirect Effect through Polymorphonuclear Cells

Anthrax toxin can induce hemolysis in the presence of polymorphonuclear cells (PMNs), an activity primarily mediated by protective antigen, with synergic effects provided by lethal factor and edema factor. Lethal factor and edema factor, individually or in combination, are incapable of lysing red bl...

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Bibliographic Details
Published in:The Journal of infectious diseases 2003-10, Vol.188 (8), p.1138-1141
Main Authors: Wu, Aiguo G., Alibek, Darya, Li, Yue Lydia, Bradburne, Chris, Bailey, Charles L., Alibek, Kenneth
Format: Article
Language:English
Subjects:
Anthrax
Antigens, Bacterial
Bacillus anthracis
Bacillus anthracis - metabolism
Bacillus anthracis - pathogenicity
Bacteria
Bacterial Toxins - pharmacology
Biological and medical sciences
Blood
Blood cells
Edema
edema factor
Erythrocytes
Fundamental and applied biological sciences. Psychology
Hemoglobins
Hemoglobins - analysis
Hemolysis
Hemolysis - drug effects
Humans
Infectious diseases
lethal factor
Medical sciences
Microbiology
Neutrophils
Neutrophils - drug effects
Toxins
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Summary:Anthrax toxin can induce hemolysis in the presence of polymorphonuclear cells (PMNs), an activity primarily mediated by protective antigen, with synergic effects provided by lethal factor and edema factor. Lethal factor and edema factor, individually or in combination, are incapable of lysing red blood cells. The requirement for the presence of PMNs indicates that hemolysis associated with Bacillus anthracis infection is indirect rather than direct, as observed in many other bacterial infections
ISSN:0022-1899
1537-6613
DOI:10.1086/378516