Nephrogenic diabetes insipidus in sibling colts

Nephrogenic diabetes insipidus was diagnosed in two full sibling Thoroughbred colts. Each colt had a history of excessive urination. Extreme polydipsia (greater than 80 L per day) was documented in both colts. Inability to concentrate urine in response to water deprivation, infusion of hypertonic sa...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 1993-03, Vol.7 (2), p.68-72
Main Authors: Schott, H.C. II, Bayley, W.M, Reed, S.M, Brobst, D.F
Format: Article
Language:English
Subjects:
Animals
CABALLOS
CHEVAL
DIABETE
DIABETES
Diabetes Insipidus - genetics
Diabetes Insipidus - urine
Diabetes Insipidus - veterinary
FOALS
FRATRIE
FUNCTIONAL DISORDERS
GENE RECESSIF
GENES RECESIVOS
GENETICA
GENETICS
GENETIQUE
HERMANOS
Horse Diseases - genetics
Horse Diseases - urine
HORSES
Kidney Concentrating Ability
Kidney Diseases - genetics
Kidney Diseases - urine
Kidney Diseases - veterinary
Male
POLYDIPSIA
POLYURIA
POTRO
POULAIN
RECESSIVE GENES
SEX
SEX LINKAGE
SEXE
SEXO
SIBLINGS
SINTOMAS
SYMPTOME
SYMPTOMS
TRASTORNOS DE LA ORINA
TRASTORNOS FUNCIONALES
TROUBLE FONCTIONNEL
TROUBLE URINAIRE
URINATION DISORDERS
Vasopressins
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Description
Summary:Nephrogenic diabetes insipidus was diagnosed in two full sibling Thoroughbred colts. Each colt had a history of excessive urination. Extreme polydipsia (greater than 80 L per day) was documented in both colts. Inability to concentrate urine in response to water deprivation, infusion of hypertonic saline, or exogenous vasopressin administration indicated insensitivity of the collecting duct epithelial cells to vasopressin. A diagnosis of nephrogenic diabetes insipidus was further supported by a normal increase in plasma vasopressin concentration after water deprivation in the one colt in which such testing was pursued.
ISSN:0891-6640
1939-1676