T‐cell alloreactivity dominates natural killer cell alloreactivity in minimally T‐cell‐depleted HLA‐non‐identical paediatric bone marrow transplantation

Natural killer (NK) cell alloreactivity resulting from killer immunoglobulin‐like receptor (KIR) ligand incompatibility improves outcomes in patients receiving extensively T‐cell‐depleted bone marrow (BM) grafts. Patients with KIR ligand incompatibility are at risk for donor T‐cell alloreactivity. W...

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Bibliographic Details
Published in:British journal of haematology 2003-10, Vol.123 (2), p.323-326
Main Authors: Lowe, Eric J., Turner, Victoria, Handgretinger, Rupert, Horwitz, Edwin M., Benaim, Ely, Hale, Gregory A., Woodard, Paul, Leung, Wing
Format: Article
Language:English
Subjects:
Adolescent
Adult
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
bone marrow transplantation
Bone Marrow Transplantation - immunology
Bone marrow, stem cells transplantation. Graft versus host reaction
Child
Child, Preschool
Female
Graft vs Host Disease - immunology
Hematologic Neoplasms - therapy
Hematology
Histocompatibility Testing
human leucocyte antigen (HLA)
Humans
Infant
Killer Cells, Natural - immunology
Lymphocyte Depletion
Male
Medical sciences
Multivariate Analysis
natural killer cells
paediatric
Recurrence
Risk Factors
T-Lymphocytes - immunology
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Treatment Outcome
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Summary:Natural killer (NK) cell alloreactivity resulting from killer immunoglobulin‐like receptor (KIR) ligand incompatibility improves outcomes in patients receiving extensively T‐cell‐depleted bone marrow (BM) grafts. Patients with KIR ligand incompatibility are at risk for donor T‐cell alloreactivity. We investigated the relative significance of NK‐cell and T‐cell alloreactivity in 105 paediatric patients who received a minimally T‐cell‐depleted human leucocyte antigen‐non‐identical BM transplantation. Donor NK‐cell incompatibility did not improve patient outcome [engraftment, graft‐versus‐host disease (GVHD), relapse or overall survival]. In contrast, donor T‐cell incompatibility was a risk factor for acute GVHD, chronic GVHD and death. Thus, T‐cell alloreactivity dominated that of NK cells in minimally T‐cell‐depleted grafts.
ISSN:0007-1048
1365-2141
DOI:10.1046/j.1365-2141.2003.04604.x