Lack of independence between five DNA polymorphisms in the NF1 gene

The neurofibromatosis type 1 (NF1) gene has been assigned to chromosome 17q11.2 and has since been cloned. Seven Belgian NF1 pedigrees suitably structured for segregation analysis were studied using recently reported intragenic polymorphisms with an allegedly useful rate of heterozygosity. Analysis...

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Bibliographic Details
Published in:Human molecular genetics 1993-04, Vol.2 (4), p.485-485
Main Authors: Messiaen, Ludwine, De Bie, Sylvia, Moens, Tanya, Enden, Apollonia Van den, Leroy, Jules
Format: Article
Language:English
Subjects:
Alleles
Biological and medical sciences
DNA
DNA - genetics
DNA Probes
Female
Gene Frequency
Genes, Neurofibromatosis 1
Haplotypes - genetics
Humans
Linkage Disequilibrium
Male
man
Medical sciences
Neurofibromatosis 1 - diagnosis
Neurofibromatosis 1 - genetics
Neurology
NF1 gene
polymorphism
Polymorphism, Genetic
Recklinghausen's disease
tumor suppressor genes
Tumors of the nervous system. Phacomatoses
Citations: Items that cite this one
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Description
Summary:The neurofibromatosis type 1 (NF1) gene has been assigned to chromosome 17q11.2 and has since been cloned. Seven Belgian NF1 pedigrees suitably structured for segregation analysis were studied using recently reported intragenic polymorphisms with an allegedly useful rate of heterozygosity. Analysis of this battery of polymorphisms should allow presymptomatic diagnosis in almost all NF1 families.
ISSN:0964-6906
1460-2083
DOI:10.1093/hmg/2.4.485