Prophylactic and therapeutic vaccination against a mucosal papillomavirus

1 The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Glasgow G61 1BD and 2 Department of Veterinary Pathology, Glasgow University Faculty of Veterinary Medicine, Garscube Estate, Glasgow G61 1QH, U.K. Papillomaviruses are ubiquitous DNA viruses affecting humans and...

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Bibliographic Details
Published in:Journal of general virology 1993-06, Vol.74 (6), p.945-953
Main Authors: Campo, M. Saveria, Grindlay, G. Joan, O'Neil, Brian W, Chandrachud, Lata M, McGarvie, Gail M, Jarrett, William F. H
Format: Article
Language:English
Subjects:
Animals
Antibody Formation
Applied microbiology
Biological and medical sciences
Bovine papillomavirus 1 - immunology
Bovine papillomavirus 1 - pathogenicity
Capsid - genetics
Capsid - immunology
Cattle
Cattle Diseases - immunology
Cattle Diseases - prevention & control
Fundamental and applied biological sciences. Psychology
Gastrointestinal Neoplasms - immunology
Gastrointestinal Neoplasms - prevention & control
Microbiology
Oncogene Proteins, Viral - genetics
Oncogene Proteins, Viral - immunology
Papilloma - immunology
Papilloma - prevention & control
Recombinant Fusion Proteins - genetics
Recombinant Fusion Proteins - immunology
Specific Pathogen-Free Organisms
Tumor Virus Infections - immunology
Tumor Virus Infections - prevention & control
Vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - immunology
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Summary:1 The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Garscube Estate, Glasgow G61 1BD and 2 Department of Veterinary Pathology, Glasgow University Faculty of Veterinary Medicine, Garscube Estate, Glasgow G61 1QH, U.K. Papillomaviruses are ubiquitous DNA viruses affecting humans and animals and causing a variety of tumours of mucosal and cutaneous epithelia. Some of these lesions, particularly those affecting mucosal epithelia, can progress to squamous cell carcinomas. Prevention or cure of viral infection would ultimately lead to a decrease in the incidence of papillomavirus-associated cancers. Using recombinant proteins, we have developed prophylactic and therapeutic vaccines against bovine papillomavirus type 4, a mucosal papillomavirus implicated in cancer of the alimentary canal in cattle; similar possibilities exist for the human mucosal papillomaviruses. Received 14 December 1992; accepted 12 January 1993.
ISSN:0022-1317
1465-2099
DOI:10.1099/0022-1317-74-6-945