Variation in Course of Hepatitis E in Experimentally Infected Cynomolgus Monkeys

Five cynomolgus monkeys (Macaca fascicularis) developed hepatitis after inoculation with a prototype strain of hepatitis E virus (HEV) from Pakistan. Although all 5 monkeys displayed liver enzyme elevations, viremia, virus secretion in feces, and seroconversion, two different patterns of these param...

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Bibliographic Details
Published in:The Journal of infectious diseases 1993-06, Vol.167 (6), p.1302-1306
Main Authors: Tsarev, Sergei A., Emerson, Suzanne U., Tsareva, Tatiana S., Yarbough, Patrice O., Lewis, Marianne, Govindarajan, Sugantha, Reyes, Gregory R., Shapiro, Max, Purcell, Robert H.
Format: Article
Language:English
Subjects:
Alanine Transaminase - blood
Animals
Antibodies
Antibodies, Viral - blood
Biological and medical sciences
Enzymes
Experimental viral diseases and models
Feces
Feces - microbiology
Genomes
Hepatitis
Hepatitis E - microbiology
Hepatitis E - pathology
Hepatitis E - physiopathology
Hepatitis E virus
Hepatitis E virus - isolation & purification
Infections
Infectious diseases
Liver
Liver - pathology
Macaca fascicularis
Major Articles
Medical sciences
Polymerase Chain Reaction
Viral diseases
Viremia
Viruses
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Summary:Five cynomolgus monkeys (Macaca fascicularis) developed hepatitis after inoculation with a prototype strain of hepatitis E virus (HEV) from Pakistan. Although all 5 monkeys displayed liver enzyme elevations, viremia, virus secretion in feces, and seroconversion, two different patterns of these parameters were observed. For 4 monkeys, increased alanine aminotransferase (ALT) activity was first observed on days 21-26, viremia occurred before and during enzyme elevation, and the animals seroconverted coincidentally with the end ofviremia or shortly thereafter. One of these monkeys had a more severe hepatitis, with peak ALT values more than twice the peak levels of the other monkeys. The fifth monkey developed biphasic hepatitis with peaks of ALT activity on days 26 and 54. In this case, viremia and seroconversion were correlated only with the second peak of enzyme elevation and liver histopathology only with the first peak. Viral shedding in this fifth animal lasted two times longer than in other animals.
ISSN:0022-1899
1537-6613
DOI:10.1093/infdis/167.6.1302