The Capillary Gas Chromatographic Determination of Trazodone in Biological Specimens

A simple and specific method is presented for the capillary gas chromatographic determination of trazodone in postmortem blood and tissues. The drug and trimethobenzamide, which was used as an internal standard, were extracted with 1% isopropanol in n-butyl chloride. Chromatography was accomplished...

Full description

Saved in:
Bibliographic Details
Published in:Journal of analytical toxicology 1984-09, Vol.8 (5), p.217-219
Main Authors: Anderson, W.H., Archuleta, M.M.
Format: Article
Language:English
Subjects:
Analysis
Biological and medical sciences
Blood
Chloride
Chromatography
Chromatography, Gas - methods
Data processing
Drugs
General pharmacology
Humans
Hydrogen
Medical sciences
Pharmacology. Drug treatments
Piperazines - analysis
Silicones
Solvents
Trazodone - analysis
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A simple and specific method is presented for the capillary gas chromatographic determination of trazodone in postmortem blood and tissues. The drug and trimethobenzamide, which was used as an internal standard, were extracted with 1% isopropanol in n-butyl chloride. Chromatography was accomplished with a short (4-m) methyl silicone capillary column and hydrogen carrier gas. This combination of extraction solvent and chromatographic conditions was demonstrated to be both accurate and precise. Since trazodone is a relatively new drug, additional thin layer and packed column gas chromatographic data is presented to augment the incorporation of trazodone into routine analytical protocols.
ISSN:0146-4760
1945-2403
DOI:10.1093/jat/8.5.217