Common Forms of Synaptic Plasticity in the Hippocampus and Neocortex in Vitro

Activity-dependent synaptic plasticity in the superficial layers of juvenile cat and adult rat visual neocortex was compared with that in adult rat hippocampal field CA1. Stimulation of neocortical layer IV reliably induced synaptic long-term potentiation (LTP) and long-term depression (LTD) in laye...

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Published in:Science (American Association for the Advancement of Science) 1993-06, Vol.260 (5113), p.1518-1521
Main Authors: Kirkwood, Alfredo, Dudek, Serana M., Gold, Joel T., Aizenman, Carlos D., Bear, Mark F.
Format: Article
Language:English
Subjects:
Action Potentials
Aging - physiology
Animals
Biological and medical sciences
Brain
Cats
Central nervous system
Central neurotransmission. Neuromudulation. Pathways and receptors
Cerebral Cortex - physiology
Electric Stimulation
Fundamental and applied biological sciences. Psychology
Hippocampus
Hippocampus (Brain)
Hippocampus - physiology
In Vitro Techniques
Long term depression
Long term potentiation
N methyl D aspartate receptors
Neocortex
Neural Pathways - physiology
Neuronal Plasticity - physiology
Neurons
Neuroplasticity
Physiological aspects
Rats
Receptors, N-Methyl-D-Aspartate - physiology
Synapses - physiology
Vertebrates: nervous system and sense organs
Visual cortex
White matter
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Summary:Activity-dependent synaptic plasticity in the superficial layers of juvenile cat and adult rat visual neocortex was compared with that in adult rat hippocampal field CA1. Stimulation of neocortical layer IV reliably induced synaptic long-term potentiation (LTP) and long-term depression (LTD) in layer III with precisely the same types of stimulation protocols that were effective in CA1. Neocortical LTP and LTD were specific to the conditioned pathway and, as in the hippocampus, were dependent on activation of N-methyl-D-aspartate receptors. These results provide strong support for the view that common principles may govern experience-dependent synaptic plasticity in CA1 and throughout the superficial layers of the mammalian neocortex.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.8502997