DNA hypermethylation is associated with 17p allelic loss in neural tumors

It has long been debated whether the accumulation of allelic losses in tumors involves the selection of cells which have stochastically lost chromosomal regions or whether there is, inherent to the neoplastic state, a process which predisposes to genetic instability. Changes in DNA methylation are c...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1993-06, Vol.53 (12), p.2715-2718
Main Authors: MAKOS, M, NELKIN, B. D, CHAZIN, V. R, CAVENEE, W. K, BRODEUR, G. M, BAYLIN, S. B
Format: Article
Language:English
Subjects:
Alleles
Astrocytoma - genetics
Astrocytoma - metabolism
Biological and medical sciences
Brain Neoplasms - genetics
Brain Neoplasms - metabolism
Chromosome Deletion
Chromosomes, Human, Pair 17
DNA, Neoplasm - metabolism
Glioblastoma - genetics
Glioblastoma - metabolism
Humans
Medical sciences
Methylation
Neuroblastoma - genetics
Neuroblastoma - metabolism
Neurology
Tumors of the nervous system. Phacomatoses
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Summary:It has long been debated whether the accumulation of allelic losses in tumors involves the selection of cells which have stochastically lost chromosomal regions or whether there is, inherent to the neoplastic state, a process which predisposes to genetic instability. Changes in DNA methylation are commonly seen in human tumors and can alter chromosome structure. We now have examined specific types of primary neural tumors which allow us to determine relationships between abnormal DNA hypermethylation and allelic loss. In primary brain tumors which frequently lose chromosome 17p (30-50%) even in the earliest stages, we now show that 84% (21 of 25) exhibit hypermethylation at locus D17S5, on 17p. However, in primary neuroblastomas, a tumor type which does not lose chromosome 17p, no regional hypermethylation is observed. These data suggest that on chromosome 17p, regional D17S5 hypermethylation constitutes a molecular change which is associated with genetic instability.
ISSN:0008-5472
1538-7445